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DOI: 10.1055/s-2006-925176
Morphological and Histopathological Changes in Tongues of Experimentally Developed Acromegaly-like Rats
Publication History
Received 11 July 2005
Accepted after revision 9 November 2005
Publication Date:
27 April 2006 (online)
![](https://www.thieme-connect.de/media/hmr/200603/lookinside/thumbnails/10.1055-s-2006-925176-1.jpg)
Abstract
An acromegaly-like rat model recently developed by exogenous administration of insulin-like growth factor I (IGF-I) was used to investigate morphological and histopathological tongue changes and clarify whether the changes were reversible. Human recombinant IGF-I (640 µg/day) was continuously subcutaneously infused into ten-week-old male rats for four weeks (IGF-I group; n = 6). Control sham-operated animals were injected saline alone (control group; n = 6). Rats were sacrificed immediately on ending administration at the age of fourteen weeks. Another 12 rats (6 from each group) were housed for an additional four weeks after administration ended. Total IGF-I (human + rat) increased significantly during administration, returning to control levels afterwards. Tongue weights significantly increased with histopathological changes present (increases in the muscle-bundle width, spaces between muscle-bundles and epithelium thickness) in the IGF-I group compared to control rats. Tongue size returned to control levels after discontinuation of IGF-I administration. These findings suggest that the characteristic tongue enlargement was developed experimentally in our acromegaly-like rat model, and that such morphological and histopathological tongue changes are reversible on normalization of circulating IGF-I levels.
Key words
Acromegaly - rat model - IGF-I - tongue enlargement - oral soft tissues
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Dr. Akane Kobayashi
Department of Oral Diagnosis · Tohoku University Graduate School of Dentistry ·
4-1 Seiryo-machi · Aoba-ku · Sendai 980-8575 · Japan
Phone: +81 (22) 717-8390
Fax: +81 (22) 717-8393 ·
Email: akane-tin@umin.ac.jp