Endoscopy 2006; 38(3): 266-270
DOI: 10.1055/s-2006-925026
Short Communication
© Georg Thieme Verlag KG Stuttgart · New York

Hyperplastic Polyposis Coli Syndrome and Colorectal Carcinoma

C.  A.  Rubio1 , S.  Stemme1 , E.  Jaramillo2 , A.  Lindblom3
  • 1Department of Pathology, Karolinska University Hospital, Stockholm, Sweden
  • 2Department of Endoscopy, Karolinska University Hospital, Stockholm, Sweden
  • 3Department of Molecular Medicine and Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden
Weitere Informationen

Publikationsverlauf

Submitted 6 April 2005

Accepted after revision 30 June 2005

Publikationsdatum:
10. März 2006 (online)

Background: Patients with hyperplastic polyposis coli syndrome (HPCS) have a propensity to develop colorectal carcinoma (CRC).
Patients and Methods: Details were retrieved from the files of patients attending our hospital between 1988 and 2004 who fulfilled the World Health Organization criteria for HPCS.
Results: Over a period of 16 years, 10 cases of HPCS were identified at our hospital (0.625 cases/year or one case every 1.6 years). A mean of 40.3 hyperplastic polyps per patient were found (range 6 - 159). Other colorectal lesions were found as follows: two patients each had one mixed polyp; there were 15 serrated adenomas in eight patients; and there were 30 tubular, tubulovillous, or villous adenomas in eight patients. Among the 10 patients with HPCS, seven developed a CRC. Of the four villous adenomas, three were associated with a CRC, but only one of the 15 serrated adenomas was associated with a CRC. The pathway of cancer evolution in HPCS patients remains unresolved.
Conclusions: Similarly to our results, a review of the literature indicates a high incidence of CRCs in HPCS patients. These patients are at a high risk of developing a CRC and should therefore receive regular colonoscopic surveillance.

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C. A. Rubio, MD, PhD

Gastrointestinal and Liver Pathology Research Laboratory · Department of Pathology · Karolinska Institute and University Hospital

17176 Stockholm · Sweden

Fax: +46-8-51774524·

eMail: Carlos.Rubio@onkpat.ki.se