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DOI: 10.1055/s-2006-924974
Relationship Between Serum Concentrations of Interleukin-6 and Tumor Necrosis Factor Alpha in Female Turkish Subjects with Normal and Impaired Glucose Tolerance
Publication History
Received 1 March 2005
Accepted after revision 11 August 2005
Publication Date:
13 February 2006 (online)
![](https://www.thieme-connect.de/media/hmr/200601/lookinside/thumbnails/10.1055-s-2006-924974-1.jpg)
Abstract
Serum interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNFα) concentrations were measured in subjects during two-hour glucose loading in order to investigate the effects of glucose on serum IL-6 and TNFα concentrations. Twenty-six female subjects (mean age 60 ± 10 years) had normal glucose tolerance (NGT ) and nineteen female subjects (mean age: 63 ± 9 years) had impaired glucose tolerance (IGT ) according to WHO criteria. Serum IL-6 and TNFα concentrations were measured by chemiluminescent immunometric assay. Subjects with IGT have higher fasting serum TNFα levels than subjects with NGT (p < 0.01). Serum IL-6 and TNFα concentrations were elevated during glucose loading (for each comparision, p < 0.01). The increase in serum TNFα concentrations in IGT was greater than in NGT (p < 0.01). Serum IL-6 and TNFα concentration significantly correlated with insulin and glucose in IGT group (for each comparision, p < 0.01). The correlation between serum glucose and cytokines concentrations was significant in IGT (for each comparision, p < 0.01). There was also a positive correlation between serum IL-6 and TNFα in NGT and IGT (for each comparision, p < 0.01). In conclusion, hyperglycemia is associated with increased circulating cytokine concentrations and fasting TNFα concentrations seem to be more associated with IGT than IL-6.
Key words
Interleukin-6 - tumor necrosis factor-alpha - hyperglycemia - impaired glucose tolerance - cytokines
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Dildar Konukoglu
Cerrahpasa Medical Faculty · Department of Biochemistry · Istanbul University
Fatih Sitesi B-4 Blok · Daire 5 · Silivrikapı · Fatih · Istanbul · Turkey
Email: dkonuk@istanbul.edu.tr