Experimental Use of N-Butyl Cyanoacrylate Tissue Adhesive on Lung Parenchyma after Pulmonary Resection

Abstract

Background: The aim of this study was to investigate the effectiveness of N-butyl cyanoacrylate tissue adhesive for the prevention of air leak together with the morphological changes to lung parenchyma. Methods: Twelve New Zealand rabbits were used. The rabbits were ventilated with pressure-controlled ventilation during the experiment, beginning with a pressure level of 10 cm H₂O. After a 2 × 2-cm pulmonary wedge resection, the resection surface was sealed with N-butyl cyanoacrylate and the pressure level was increased every five minutes in 5-cm H₂O increments. The pressure level which caused an air leak from the resection surface was recorded. The morphological damage to the lung parenchyma was evaluated under light microscopy. Results: The mean value of the pressure levels that caused air leak was 43.3 ± 8.8 cm H₂O. No tissue damage to lung parenchyma was recorded after histopathological examination. Conclusion: N-butyl cyanoacrylate was effective in preventing air leak from the pulmonary resection surface even with high airway pressure levels. It could be used as an aid for pulmonary resection lines or to control the air leak from pulmonary parenchyma.

Key words

cardiovascular surgery - heart and lung transplantation - thoracic surgery

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