J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York
Postprandial Mononuclear NF-κB Activation is Independent of the AGE-content of a Single Meal
S. Schiekofer1,5
, S. Franke,2
, M. Andrassy1,6
, J. Chen,1,7
, G. Rudofsky1
, J. G. Schneider,1
, M. von Eynatten1
, T. Wendt,1
, M. Morcos1
, R. Kientsch-Engel,3
, G. Stein2
, E. Schleicher,4
, P. P. Nawroth1
, A. Bierhaus1
1Department of Medicine I, University of Heidelberg, Heidelberg, Germany
2Department of Medicine IV, University of Jena, Jena, Germany
3Roche Diagnostics GmbH, Penzberg, Germany
4Department of Medicine IV, University of Tübingen, Tübingen, Germany
5Department of Medicine I, University of Ulm, Ulm, Germany
6Department of Medicine III, University of Heidelberg, Heidelberg, Germany
7Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Further Information
Publication History
Received: December 9, 2005
First decision: January 24, 2006
ABTS 2.2-azino-di-[3-ethylbenzthiazoline sulfonate]diammonium salt
AGE's advanced glycation endproducts
CML Nε-(carboxymethyl)lysine
ELISA enzyme-linked immunoabsorbant assay
EMSA electrophoretic mobility shift assay
G-casein glucose casein
NF-κB nuclear factor-kappa B
pBMC peripheral blood mononuclear cells
RAGE receptor for AGE
ROS reactive oxygen species
S-casein sorbitol casein
SD standard deviation
TBE tris-borate-EDTA
TBS tris-buffered saline
References
1
Ahmed N, Mirshekar-Syahkal B, Kennish L, Karachalias N, Babaei-Jadidi R, Thornalley P J.
Assay of advanced glycation endproducts in selected beverages and food by liquid chromatography with tandem mass spectrometric detection.
Mol Nutr Food Res.
2005;
49
691-699
2
Aljada A, Mohanty P, Ghanim H, Abdo T, Tripathy D, Chaudhuri A, Dandona P.
Increase in intranuclear nuclear factor kappaB and decrease in inhibitor kappaB in mononuclear cells after a mixed meal: evidence for a proinflammatory effect.
Am J Clin Nutr.
2004;
79
682-690
3
Bierhaus A, Schiekofer S, Schwaninger M, Andrassy M, Humpert P M, Chen J, Hong M, Luther T, Henle T, Kloting I. et al .
Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB.
Diabetes.
2001;
50
2792-2808
4
Cai W, Gao Q D, Zhu L, Peppa M, He C, Vlassara H.
Oxidative stress-inducing carbonyl compounds from common foods: novel mediators of cellular dysfunction.
Mol Med.
2002;
8
337-346
5
Careche M, Lobato M F, Ros M, Moreno F J, Garcia-Ruiz J P.
Influence of starvation/refeeding transition on lipogenesis and NADPH producing systems in adipose tissue, mammary gland and liver at mid-lactation.
Horm Metab Res.
1985;
17
226-229
6
Ceriello A, Quagliaro L, Piconi L, Assaloni R, Da Ros R, Maier A, Esposito K, Giugliano D.
Effect of postprandial hypertriglyceridemia and hyperglycemia on circulating adhesion molecules and oxidative stress generation and the possible role of simvastatin treatment.
Diabetes.
2004;
53
701-710
7
Chung H Y, Kim H J, Kim J W, Yu B P.
The inflammation hypothesis of aging: molecular modulation by calorie restriction.
Ann NY Acad Sci.
2001;
928
327-335
8
Dandona P, Mohanty P, Hamouda W, Ghanim H, Aljada A, Garg R, Kumar V.
Inhibitory effect of a two day fast on reactive oxygen species (ROS) generation by leucocytes and plasma ortho-tyrosine and meta-tyrosine concentrations.
J Clin Endocrinol Metab.
2001;
86
2899-2902
9
Devasagayam T P, Tilak J C, Boloor K K, Sane K S, Ghaskadbi S S, Lele R D.
Free radicals and antioxidants in human health: current status and future prospects.
J Assoc Physicians India.
2004;
52
794-804
10
Exton M S, von Horsten S, Strubel T, Donath S, Schedlowski M, Westermann J.
Conditioned alterations of specific blood leukocyte subsets are reconditionable.
Neuroimmunomodulation.
2000;
7
106-114
11
Faist V, Muller C, Drusch S, Erbersdobler H F.
Selective fortification of lysinoalanine, fructoselysine and N epsilon-carboxymethyllysine in casein model systems.
Nahrung.
2001;
45
218-221
13
Goldberg T, Cai W, Peppa M, Dardaine V, Baliga B S, Uribarri J, Vlassara H.
Advanced glycoxidation end products in commonly consumed foods.
J Am Diet Assoc.
2004;
104
1287-1291
17
Hofmann M A, Schiekofer S, Isermann B, Kanitz M, Henkels M, Joswig M, Treusch A, Morcos M, Weiss T, Borcea V. et al .
Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB.
Diabetologia.
1999;
42
222-232
18
Hofmann M A, Schiekofer S, Kanitz M, Klevesath M S, Joswig M, Lee V, Morcos M, Tritschler H, Ziegler R, Wahl P. et al .
Insufficient glycemic control increases nuclear factor-kappa B binding activity in peripheral blood mononuclear cells isolated from patients with type 1 diabetes.
Diabetes Care.
1998;
21
1310-1316
19
Hofmann S M, Dong H J, Li Z, Cai W, Altomonte J, Thung S N, Zeng F, Fisher E A, Vlassara H.
Improved insulin sensitivity is associated with restricted intake of dietary glycoxidation products in the db/db mouse.
Diabetes.
2002;
51
2082-2089
20
Hofmann T, Bors W, Stettmaier K.
Radical-assisted melanoidin formation during thermal processing of foods as well as under physiological conditions.
J Agric Food Chem.
1999;
47
391-396
23
McCarty M F.
The low-AGE content of low-fat vegan diets could benefit diabetics - though concurrent taurine supplementation may be needed to minimize endogenous AGE production.
Med Hypotheses.
2005;
64
394-398
24
Miyata T, Ueda Y, Shinzato T, Lida Y, Tanaka S, Kurokawa K, van Ypersele de Strihou C, Maeda K.
Accumulation of albumin-linked and free-form pentosidine in the circulation of uremic patients with end-stage renal failure: renal implications in the pathophysiology of pentosidine.
J Am Soc Nephrol.
1996;
7
1198-1206
25
Mohanty P, Ghanim H, Hamouda W, Aljada A, Garg R, Dandona P.
Both lipid and protein intakes stimulate increased generation of reactive oxygen species by polymorphonuclear leukocytes and mononuclear cells.
Am J Clin Nutr.
2002;
75
767-772
27
Nappo F, Esposito K, Cioffi M, Giugliano G, Molinari A M, Paolisso G, Marfella R, Giugliano D.
Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals.
J Am Coll Cardiol.
2002;
39
1145-1150
28
Nestares T, Lopez-Jurado M, Urbano G, Seiquer I, Ramirez-Tortosa M C, Ros E, Mataix J, Gil A.
Effects of lifestyle modification and lipid intake variations on patients with peripheral vascular disease.
Int J Vitam Nutr Res.
2003;
73
389-398
30
Peppa M, Brem H, Ehrlich P, Zhang J G, Cai W, Li Z, Croitoru A, Thung S, Vlassara H.
Adverse effects of dietary glycotoxins on wound healing in genetically diabetic mice.
Diabetes.
2003;
52
2805-2813
31
Peppa M, Goldberg T, Cai W, Rayfield E, Vlassara H.
Glycotoxins: a missing link in the “relationship of dietary fat and meat intake in relation to risk of type 2 diabetes in men”.
Diabetes Care.
2002;
25
1898-1899
32
Rudofsky Jr G, Reismann P, Schiekofer S, Petrov D, Eynatten M, Humpert P M, Isermann B, Muller-Hoff C, Thai T P, Lichtenstein S. et al .
Reduction of postprandial hyperglycemia in patients with type 2 diabetes reduces NF-kappaB activation in PBMCs.
Horm Metab Res.
2004;
36
630-638
33
Schiekofer S, Andrassy M, Chen J, Rudofsky G, Schneider J, Wendt T, Stefan N, Humpert P, Fritsche A, Stumvoll M. et al .
Acute hyperglycemia causes intracellular formation of CML and activation of ras, p 42/44 MAPK, and nuclear factor kappaB in PBMCs.
Diabetes.
2003;
52
621-633
34
Schleicher E D, Wagner E, Nerlich A G.
Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging.
J Clin Invest.
1997;
99
457-468
35
Schmidt A M, Yan S D, Yan S F, Stern D M.
The biology of the receptor for advanced glycation end products and its ligands.
Biochim Biophys Acta.
2000;
1498
99-111
36
Sebekova K, Krajcoviova-Kudlackova M, Schinzel R, Faist V, Klvanova J, Heidland A.
Plasma levels of advanced glycation end products in healthy, long-term vegetarians and subjects on a western mixed diet.
Eur J Nutr.
2001;
40
275-281
37
Stern D, Yan S D, Yan S F, Schmidt A M.
Receptor for advanced glycation endproducts: a multiligand receptor magnifying cell stress in diverse pathologic settings.
Adv Drug Deliv Rev.
2002;
54
1615-1625
38
Talior I, Yarkoni M, Bashan N, Eldar-Finkelman H.
Increased glucose uptake promotes oxidative stress and PKC-delta activation in adipocytes of obese, insulin-resistant mice.
Am J Physiol Endocrinol Metab.
2003;
285
E295-302
39
Uribarri J, Peppa M, Cai W, Goldberg T, Lu M, Baliga S, Vassalotti J A, Vlassara H.
Dietary glycotoxins correlate with circulating advanced glycation end product levels in renal failure patients.
Am J Kidney Dis.
2003;
42
532-538
40
Vidal-Puig A J, Grujic D, Zhang C Y, Hagen T, Boss O, Ido Y, Szczepanik A, Wade J, Mootha V, Cortright R. et al .
Energy metabolism in uncoupling protein 3 gene knockout mice.
J Biol Chem.
2000;
275
16258-16266
41
Vlassara H, Cai W, Crandall J, Goldberg T, Oberstein R, Dardaine V, Peppa M, Rayfield E J.
Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy.
Proc Natl Acad Sci USA.
2002;
99
15596-15601
43
Zheng F, He C, Cai W, Hattori M, Steffes M, Vlassara H.
Prevention of diabetic nephropathy in mice by a diet low in glycoxidation products.
Diabetes Metab Res Rev.
2002;
18
224-237
44
Zill H, Bek S, Hofmann T, Huber J, Frank O, Lindenmeier M, Weigle B, Erbersdobler H F, Scheidler S, Busch A E. et al .
RAGE-mediated MAPK activation by food-derived AGE and non-AGE products.
Biochem Biophys Res Commun.
2003;
300
311-315