Efficient One-Pot Synthesis of 1-Aryl 1,2,3-Triazoles from Aryl Halides and Terminal Alkynes in the Presence of Sodium Azide

Jacob Andersen; Simon Bolvig; Xifu Liang

doi:10.1055/s-2005-921887

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Synlett 2005(19): 2941-2947
DOI: 10.1055/s-2005-921887

LETTER

Efficient One-Pot Synthesis of 1-Aryl 1,2,3-Triazoles from Aryl Halides and Terminal Alkynes in the Presence of Sodium Azide

Jacob Andersen^a, Simon Bolvig^b, Xifu Liang*^a
^a Department of Medicinal Chemistry, LEO Pharma, Industriparken 55, 2750 Ballerup, Denmark
Fax: +45(7226)3320; e-Mail: xifu.liang@leo-pharma.com;
^b Department of Spectroscopy and Physical Chemistry, LEO Pharma, Industriparken 55, 2750 Ballerup, Denmark

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Publication History

Received 1 September 2005
Publication Date:
27 October 2005 (online)

Abstract
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Abstract

An efficient one-pot synthesis of 1-aryl 1,2,3-triazoles from aryl bromides/iodides and terminal alkynes in the presence of sodium azide is described. In the case of aryl iodides, the reactions proceeded at room temperature. The reactions normally gave high yields.

Key words

1,2,3-triazoles - one-pot - copper - 1,3-dipolar cycloaddition - catalyst

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