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Synthesis 2006(1): 156-160
DOI: 10.1055/s-2005-921754
DOI: 10.1055/s-2005-921754
PAPER
© Georg Thieme Verlag Stuttgart · New York
A Convenient Synthesis of 4,5-Disubstituted 1,2,4-Triazoles Functionalized in Position 3
Further Information
Received
28 April 2005
Publication Date:
16 December 2005 (online)
Publication History
Publication Date:
16 December 2005 (online)
Abstract
A convenient approach to 4,5-disubstituted 3-hydroxymethyl-1,2,4-triazoles as well as to the corresponding 3-chloromethyl and 3-carboxaldehyde derivatives was developed starting from 3-mercapto-1,2,4-triazoles which can, in turn, be readily obtained from acyl hydrazines and isothiocyanates.
Key words
alcohols - aldehydes - heterocycles - oxidations - 1,2,4-triazoles
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