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Synfacts 2006(1): 0042-0042  
DOI: 10.1055/s-2005-921741
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

C1-Aminosulfoximines in Copper-Catalyzed Asymmetric Mukaiyama-Aldol Reactions

Contributor(s): Hisashi Yamamoto, Matthew B. Boxer
M. Langner, P. Rémy, C. Bolm*
RWTH Aachen, Germany
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Publikationsdatum:
16. Dezember 2005 (online)

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Significance

The Mukaiyama-aldol reaction is a very powerful method for the formation of β-hydroxy carbonyls. While reports of the asymmetric variant are known, the authors describe a nice system that has been optimized for a broad substrate scope to produce a variety of chiral tertiary alcohols. In addition to the Mukaiyama-aldol reaction, the authors report the synthesis of a variety of C1-symmetric aryl-bridged aminosulfoximines.