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Synfacts 2006(1): 0072-0072
DOI: 10.1055/s-2005-921713
DOI: 10.1055/s-2005-921713
Bioorganic Chemistry and Organocatalysis
© Georg Thieme Verlag Stuttgart · New York
Brønsted Acid Catalyzed Highly Enantioselective Transfer Hydrogenation of Ketimines
S. Hoffmann, A. M. Seayad, B. List*
Max-Planck-Institut für Kohlenforschung, Mülheim an der Ruhr, Germany
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
16. Dezember 2005 (online)
Significance
An efficient organocatalytic asymmetric ketimine reduction is described. This reaction is mediated by a phosphoric acid derivative (only 1 mol%) in the presence of a commercially available Hantzsch ester under simple and mild conditions to provide amines in high yields and enantioselectivities. This transfer hydrogenation works well with both aliphatic and aromatic substrates and various functional groups are well tolerated.