Synthesis of 2,3-Dihydroimidazo[1,2-b]isoquinoline-5(1H)-one and Derivatives

Abstract

A novel and efficient synthesis of 2,3-dihydroimidazo[1,2-b]isoquinoline-5(1H)-one by microwave irradiation is reported. Several new derivatives of 2,3-dihydroimidazo[1,2-b]isoquinoline-5(1H)-one have been synthesized by acylation using DMAP as catalyst. A kinetic study employing HPLC allowed the determination of the N- and C-acylated isomers formed.

Key words

acylation - DMAP - isomerizations - heterocycles - microwave synthesis

References

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