Development of New Methodologies for Entry to Targets of Therapeutic Interest

Helen M. I. Osborn

doi:10.1055/s-2005-917076

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Synlett 2005(17): 2571-2586
DOI: 10.1055/s-2005-917076

ACCOUNT

Development of New Methodologies for Entry to Targets of Therapeutic Interest

Helen M. I. Osborn*
School of Pharmacy, University of Reading, Whiteknights, Reading, RG6 6AD, UK
Fax: +44(118)3786331; e-Mail: h.m.i.Osborn@rdg.ac.uk;

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Publikationsverlauf

Received 23 June 2005
Publikationsdatum:
05. Oktober 2005 (online)

Abstract
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Abstract

This Account provides an overview of strategies that have been reported from our laboratories for the synthesis of targets of therapeutic interest, namely carbohydrates, and prodrugs for the treatment of melanoma. These programmes have involved the development of new synthetic methodologies including the regio- and stereoselective synthesis of specific carbohydrate isomers, and new protecting group methodologies. This review provides an insight into the progress of these research themes, and suggests some applications for the targets that are currently being explored.

1 Carbohydrate Targets
1.1 The Development of Regioselective Protection and Glycosidation Protocols
1.2 The Stereoselective Synthesis of α-Linked GlcNAc and
β-Linked ManNAc Residues
1.3 Development of Methodology for the Synthesis of Multivalent Carbohydrate Arrays
1.4 Development of Methodology for the Synthesis of Glycosidase Inhibitors
2 The Design and Analysis of Novel Prodrugs for the Treatment of Melanoma
3 Development of Tyrosinase Labile Protecting Groups for Amines

Key words

carbohydrates - prodrugs - regioselective - stereoselective - melanoma

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