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Synfacts 2005(2): 0255-0255  
DOI: 10.1055/s-2005-916121
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Direct Acylation of Alkynes via Alkynylaluminium Compounds

Contributor(s): Paul Knochel, Andrei Gavryushin
B. Wang, M. Bonin, L. Micouin*
CNRS, Paris, France
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Publication History

Publication Date:
25 October 2005 (online)

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Significance

The developed method is a very operationally simple procedure for the acylation of terminal acetylenes to obtain ynones. Neither separate formation of metal acetylides nor transition metal catalysis is required. The use of oxalyl chloride gives an expeditive access to diynones.