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Synfacts 2005(2): 0246-0246  
DOI: 10.1055/s-2005-916118
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Radical Coupling of Ene-ynes and Haloalkenes Promoted by Indium Hydrides

Contributor(s): Paul Knochel, Andrei Gavryushin
N. Hayashi, I. Shibata, A. Baba*
Osaka University, Japan
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Publication History

Publication Date:
25 October 2005 (online)

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Significance

A newly developed mild protocol for the generation of dihalogenindium hydrides is described. This new promising reagent allows performing a number of inter- and intramolecular radical reactions with highly sensitive substrates. It generates efficiently the InCl2 radical in the presence of catalytic amounts of Et3B.