A Stable and Versatile P-Chiral Phosphine Ligand

Significance

Using the optically active, air stable QuinoxP* ligand, several asymmetric transformations can be performed with extremely high yield and enantioselectivity. QuinoxP* promotes the Rh-catalyzed asymmetric hydrogenation of alkenes, the Rh-catalyzed Michael addition of boronic acids to enones, and the Pd-catalyzed addition of dialkylzincs to oxabicyclic alkenes; approaching the upper limits of reported enantioselectivity for these three, very different reactions.