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Synfacts 2005(2): 0233-0233
DOI: 10.1055/s-2005-916073
DOI: 10.1055/s-2005-916073
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Zn-Catalyzed Aldol Reaction of Methyl Vinyl Ketone
B. M. Trost*, S. Shin, J. A. Sclafani
Stanford University, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
25. Oktober 2005 (online)
Significance
Methyl vinyl ketone (MVK) is typically base sensitive, but functions as an effective bifunctional building block for the Zn-catalyzed aldol reaction under neutral conditions. This first example of asymmetric aldol reaction using MVK works well with numerous aliphatic aldehydes, yielding products of good ee and in moderate to good yield.