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Synfacts 2005(2): 0184-0184  
DOI: 10.1055/s-2005-916047
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (-)-Dragmacidin F

Contributor(s): Philip Kocienski
N. K. Garg, D. D. Caspi, B. M. Stoltz*
California Institute Of Technology, USA
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Publikationsverlauf

Publikationsdatum:
25. Oktober 2005 (online)

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Significance

Dragmacidin F is isolated from a Mediterranean Halicortex sponge. It inhibits herpes simplex virus (HSV-I; EC50 = 95.8 µM) and human immunodeficiency virus (HIV-I; EC50 = 0.91 µM).