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Synfacts 2005(1): 0167-0167  
DOI: 10.1055/s-2005-915998
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

Immobilization of Bis(oxazolinyl)pyridines

Contributor(s): Yasuhiro Uozumi, Tomohiko Beppu
A. Cornejo, J. M. Fraíle, J. I. García, M. J. Gil, S. V. Luis, V. Martínez-Merino*, J. A. Mayoral*
Universidad Pública de Navarra, Universidad de Zaragoza-CSIC and Universidad Jaume I, Spain
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Publikationsdatum:
21. September 2005 (online)

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Significance

Bis(oxazolinyl)pyridine ligands (pybox) having various tether groups were anchored on polystyrene resin via copolymerization or grafting. The utility of the polymeric pybox ligands were examined for Ru-catalyzed asymmetric cyclopropanation of styrene. Ligand 2 showed good stability in four subsequent reuses under optimized conditions (52-70% yields, 90:10 trans/cis selectivity and 85-91% ee for trans-cyclopropanes).