Exp Clin Endocrinol Diabetes 2005; 113(9): 534-537
DOI: 10.1055/s-2005-872851
Article

J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Association of Interleukin-6, C-reactive Protein, Interleukin-10 and Adiponectin Plasma Concentrations with Measures of Obesity, Insulin Sensitivity and Glucose Metabolism

M. Blüher1 , 2 , M. Fasshauer2 , A. Tönjes2 , J. Kratzsch4 , M. R. Schön3 , R. Paschke2
  • 1Department of Internal Medicine 2, University of Köln, Köln, Germany
  • 2III. Medical Department, University of Leipzig, Leipzig, Germany
  • 3Department of Surgery, Faculty of Medicine, University of Leipzig, Leipzig, Germany
  • 4Institute of Clinical Chemistry and Pathobiochemistry, University of Leipzig, Leipzig, Germany
Further Information

Publication History

Received: March 3, 2005 First decision: April 22, 2005

Accepted: August 30, 2005

Publication Date:
19 October 2005 (online)

Abstract

Abnormal glucose tolerance is associated with subclinical chronic inflammation in patients with type 2 diabetes. The aim of this study was to investigate whether plasma concentrations of inflammatory markers are associated with measures of obesity, insulin sensitivity, and hyperglycemia. IL-6, adiponectin, CRP, and IL-10 plasma concentrations were evaluated in 142 patients with a wide range of obesity, insulin sensitivity and glucose tolerance. In parallel with the impairment of glucose tolerance, there was a significant increase in IL-6, and CRP, and a significant decrease in adiponectin and IL-10 plasma concentrations. There were significant correlations between the plasma concentrations of all inflammatory markers and % body fat, insulin sensitivity, and fasting plasma glucose. However, multivariate linear regression analysis identified insulin sensitivity as determined by glucose infusion rate during the steady state of an euglycemic-hyperinsulinemic clamp as the strongest predictor of adiponectin, CRP, IL-6, and IL-10 plasma concentrations. In addition, fasting plasma glucose was a significant determinant of adiponectin, CRP, and IL-6 plasma concentrations, whereas body fat content was only a significant predictor of CRP plasma concentration. In conclusion, our data suggest that abnormal inflammatory markers in patients with type 2 diabetes are primarily related to decreased insulin sensitivity.

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Prof. Dr. med. M. Blüher

University of Köln
Department of Internal Medicine 2

J.-Stelzmann-Str. 9

50931 Köln

Germany

Phone: + 49(0)2214785481

Fax: + 49 (0) 22 14 78 31 07

Email: bluma@medizin.uni-leipzig.de