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Synlett 2005(16): 2513-2515
DOI: 10.1055/s-2005-872699
DOI: 10.1055/s-2005-872699
LETTER
© Georg Thieme Verlag Stuttgart · New York
Selective Functionalization of Arenes through the Reaction of Aryne-Zirconocene Complexes and Enol Ethers
Further Information
Received
2 June 2005
Publication Date:
21 September 2005 (online)
Publication History
Publication Date:
21 September 2005 (online)
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Abstract
A new method for the selective functionalization of aromatic rings by the zirconium promoted cross coupling reaction of an aryllithium compound and an enol ether is reported. Formation of an aryne-zirconocene complex and its regioselective coupling with an enol ether are the key steps of the process. This methodology allows the synthesis of functionalized styrene or Z-alkenol derivatives from simple and easily available starting materials.
Key words
arynes - cross-coupling - organometallic reagents - regioselectivity - transition metals
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