Abstract
The synthesis of natural product-like compounds on solid support is described. Starting from a readily accessible d -(-)-ribose derivative, a tricyclic scaffold is prepared in five steps. After coupling onto solid supports bearing different substituents (PAL resins), the scaffold can be further derivatised at two diversity points. Representative derivatives obtained by this diversity-oriented procedure are described.
Key words
solid-phase synthesis - hetero Diels-Alder reactions - medicinal chemistry - combinatorial - furans
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