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Planta Med 2005; 71(5): 482-484
DOI: 10.1055/s-2005-871216
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Anti-Babesial Compounds from Curcuma zedoaria

Ken Kasahara1 , Shinkichi Nomura1 ,  Subeki1 , Hideyuki Matsuura1 , Masahiro Yamasaki2 , Osamu Yamato2 , Yoshimitsu Maede2 , Ken Katakura3 , Mamoru Suzuki3 ,  Trimurningsih4 ,  Chairul4 , Teruhiko Yoshihara1
  • 1Laboratory of Bioorganic Chemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
  • 2Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
  • 3Department of Parasitology, Gunma University School of Medicine, Maebashi, Japan
  • 4Research and Development for Biology, Indonesian Institute of Sciences, Bogor, Indonesia
Further Information

Publication History

Received: September 1, 2004

Accepted: January 5, 2005

Publication Date:
01 June 2005 (online)

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Abstract

Anti-babesial activity was confirmed in an extract of the bark of Curcuma zedoaria. The active ingredients were isolated, and their chemical structures were determined to be zedoalactones A, B, and C based on spectral data. Zedoalactone C is a hitherto unreported compound. The IC50 vales of these active compounds against Babesia gibsoni were compared with a standard drug, diminazene aceturate. The IC50 value of diminazene aceturate was 0.6 μg/mL, while those of zedoalactones A, B, and C were 16.5, 1.6 and 4.2 μg/mL, respectively.

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Hideyuki Matsuura

Laboratory of Bioorganic Chemistry

Division of Applied Bioscience

Graduate School of Agriculture

Hokkaido University

Sapporo 060-8589

Japan

Phone: +81-11-706-2495

Fax: +81-11-706-2505

Email: matsuura@chem.agr.hokudai.ac.jp