RSS-Feed abonnieren
DOI: 10.1055/s-2005-871216
Anti-Babesial Compounds from Curcuma zedoaria
Publikationsverlauf
Received: September 1, 2004
Accepted: January 5, 2005
Publikationsdatum:
01. Juni 2005 (online)
![](https://www.thieme-connect.de/media/plantamedica/200505/lookinside/thumbnails/10.1055-s-2005-871216-1.jpg)
Abstract
Anti-babesial activity was confirmed in an extract of the bark of Curcuma zedoaria. The active ingredients were isolated, and their chemical structures were determined to be zedoalactones A, B, and C based on spectral data. Zedoalactone C is a hitherto unreported compound. The IC50 vales of these active compounds against Babesia gibsoni were compared with a standard drug, diminazene aceturate. The IC50 value of diminazene aceturate was 0.6 μg/mL, while those of zedoalactones A, B, and C were 16.5, 1.6 and 4.2 μg/mL, respectively.
References
- 1 Grovies M G, Vanniasinghem J A. Treatment of Babesia gibsoni infections with phenamidine isothionate. Vet Rec. 1970; 86 8-10
- 2 Farewell C E, LeGrand E K, Cobb C C. Clinical observations on Babesia gibsoni and Babesia canis infections in dogs. J Am Vet Med Assoc. 1982; 180 507-11
-
3 Breitschwerd E B. Babesiosis. In: Greene C. E. editor
Infections Diseases of Dog and Cat; Greene, CE, Ed., B. W. Saunders Philadelphia; 1990: pp 796-803 - 4 Takano I, Yasuda I, Takeya K, Itokawa H. Guaiane sesquiterpene lactones from Curcuma aeruginosa . Phytochemistry. 1995; 40 1197-200
- 5 Blay G, Victoria B, Luz C, Begona G, Jose R P. Stereoselective synthesis of 7,11-guaien-8,12-olides from santonin. Synthesis of podoandin and (+)-zedoalactone A. J Org Chem. 2000; 65 6703-7
- 6 Paul V D, Eugene F, David D, Banavara L M, Ernest W. Pyridine-induced solvent shifts in the nuclear magnetic resonance spectra of hydroxylic compounds. J Am Chem Soc. 1968; 90 5480-6
- 7 Watanabe K, Shibata M, Yano S, Cai Y, Shibuya H, Kitagawa I. Antiulcer activity of extracts and isolated compounds from zedoary (gajutsu) cultivated in Yakushima (Japan). Yakugakuzasshi. 1986; 106 1137-42
- 8 Yoshioka T, Fujii E, Endo M, Shibuya H, Muraki T. Anti-inflammatory potency of dehydrocurdione, a zedoary-derived sesquiterpene. Inflammation Research. 1998; 47 476-81
- 9 Subeki , Matsuura H, Yamasaki M, Yamato O, Maede Y, Katakura K, Suzuki , Trimurningsih , Chairul , Yoshihara T. Effects of central Kalimantan plant extracts on intraerythrocytic Babesia gibsoni in culture. J Vet Med Sci. 2004; 66 871-4
Hideyuki Matsuura
Laboratory of Bioorganic Chemistry
Division of Applied Bioscience
Graduate School of Agriculture
Hokkaido University
Sapporo 060-8589
Japan
Telefon: +81-11-706-2495
Fax: +81-11-706-2505
eMail: matsuura@chem.agr.hokudai.ac.jp