Hypothalamic-pituitary-thyroid Axis in Moderate and Intense Exercise

Abstract

Exercise exerts heterogeneous effects on TSH secretion. Whereas TSH is rapidly stimulated by physical exercise within minutes, and these effects are well supported by careful experiments, the results of studies concerning intermediate and long-term response of TSH release to exercise remain unclear, and the underlying mechanism for both is still open to speculation.

Key words

TSH - Triiodothyronine - Thyroxin - Exercise

References

• 1 Buxton O M, Frank S A, L'Hermite-Baleriaux M, Leproult R, Turek F W, Van Cauter E. Roles of intensity and duration of nocturnal exercise in causing phase delays of human circadian rhythms.  Am J Physiol. 1997;  273 E536-E542
• 2 Scheen A J, Buxton O M, Jison M, Van Reeth O, Leproult R, L'Hermite-Baleriaux M, Van Cauter E. Effects of exercise on neuroendocrine secretions and glucose regulation at different times of day.  Am J Physiol. 1998;  274 E1040-E1049
• 3 Brabant G, Brabant A, Ranft U, Ocran K, Kohrle J, Hesch R D, von zur Muhlen A. Circadian and pulsatile thyrotropin secretion in euthyroid man under the influence of thyroid hormone and glucocorticoid administration.  Clin Endocrinol Metab. 1987;  65 83-88
• 4 Behrends J, Prank K, Dogu E, Brabant G. Central nervous system control of thyrotropin secretion during sleep and wakefulness.  Horm Res. 1998;  49 173-177
• 5 Romijn J A, Adriaanse R, Brabant G, Prank K, Endert E, Wiersinga W M. Pulsatile secretion of thyrotropin during fasting: a decrease of thyrotropin pulse amplitude.  J Clin Endocrinol Metab. 1990;  70 1631-1636
• 6 Samuels M H, McDaniel P A. Thyrotropin levels during hydrocortisone infusions that mimic fasting-induced cortisol elevations: a clinical research center study.  J Clin Endocrinol Metab. 1997;  82 3700-3704
• 7 Bjorbaek C, Kahn B B. Leptin signaling in the central nervous system and the periphery.  Recent Prog Horm Res. 2004;  59 305-331
• 8 Chan J L, Heist K, DePaoli A M, Veldhuis J D, Mantzoros C S. The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men.  J Clin Invest. 2003;  111 1409-1421
• 9 Richter S D, Schurmeyer T H, Schedlowski M, Hadicke A, Tewes U, Schmidt R E, Wagner T O. Time kinetics of the endocrine response to acute psychological stress.  J Clin Endocrinol Metab. 1996;  81 1956-1960
• 10 Meeusen R, Piacentini M F. Exercise, fatigue, neurotransmission and the influence of the neuroendocrine axis.  Adv Exp Med Biol. 2003;  527 521-525
• 11 Strawn J R, Ekhator N N, D'Souza B B, Geracioti T D Jr. Pituitary-thyroid state correlates with central dopaminergic and serotonergic activity in healthy humans.  Neuropsychobiology. 2004;  49 84-87
• 12 Bailey S, Davis J, Ahlborn E. Effect of increased brain serotonergic activity on endurance performance in the rat.  Acta Physiol Scand. 1992;  145 75-76
• 13 Piacentini M F, Meeusen R, Buyse L, De Schutter G, De Meirleir K. Hormonal responses during prolonged exercise are influenced by a selective DA/NA reuptake inhibitor.  Br J Sports Med. 2004;  38 129-133
• 14 Tsigos C, Chrousos G P. Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress.  J Psychosom Res. 2002;  53 865-871
• 15 Chowdhury I, Chien J T, Chatterjee A, Yu J Y. In vitro effects of mammalian leptin, neuropeptide-Y, beta-endorphin and galanin on transcript levels of thyrotropin beta and common alpha subunit mRNAs in the pituitary of bighead carp (aristichthys nobilis).  Comp Biochem Physiol B Biochem Mol Biol. 2004;  139 87-98
• 16 Brabant G, Brabant A, Ranft U, Ocran K, Kohrle J, Hesch R D, von zur Muhlen A. Circadian and pulsatile thyrotropin secretion in euthyroid man under the influence of thyroid hormone and glucocorticoid administration.  J Clin Endocrinol Metab. 1987;  65 83-88
• 17 Fukuda Y, Kageyama K, Nigawara T, Kasagi Y, Suda T. Effects of corticotropin-releasing hormone (CRH) on the synthesis and secretion of proopiomelanocortin-related peptides in the anterior pituitary: a study using CRH-deficient mice.  Neurosci Lett. 2004;  367 201-204
• 18 Parsadaniantz S M, Batsche E, Gegout-Pottie P, Terlain B, Gillet P, Netter P, Kerdelhue B. Effects of continuous infusion of interleukin 1 beta on corticotropin-releasing hormone (CRH), CRH receptors, proopiomelanocortin gene expression and secretion of corticotropin, beta-endorphin and corticosterone.  Neuroendocrinology. 1997;  65 53-63
• 19 Persson A I, Naylor A S, Jonsdottir I H, Nyberg F, Eriksson P S, Thorlin T. Differential regulation of hippocampal progenitor proliferation by opioid receptor antagonists in running and non-running spontaneously hypertensive rats.  Eur J Neurosci. 2004;  19 1847-1855
• 20 Wittmann G, Liposits Z, Lechan R M, Fekete C. Medullary adrenergic neurons contribute to the cocaine- and amphetamine-regulated transcript-immunoreactive innervation of thyrotropin-releasing hormone synthesizing neurons in the hypothalamic paraventricular nucleus.  Brain Res. 2004;  1006 1-7
• 21 Hangaard J, Andersen M, Grodum E, Koldkjaer O, Hagen C. The effects of endogenous opioids and cortisol on thyrotropin and prolactin secretion in patients with Addison's disease.  J Clin Endocrinol Metab. 1999;  84 1595-1601
• 22 Galbo H, Hummer L, Peterson I B, Christensen N J, Bie N. Thyroid and testicular hormone responses to graded and prolonged exercise in man.  Eur J Appl Physiol Occup Physiol. 1977;  14 101-106
• 23 Huang W S, Yu M D, Lee M S, Cheng C Y, Yang S P, Chin H M, Wu S Y. Effect of treadmill exercise on circulating thyroid hormone measurements.  Med Princ Pract. 2004;  13 15-19
• 24 Wesche M F, Wiersinga W M. Relation between lean body mass and thyroid volume in competition rowers before and during intensive physical training.  Horm Metab Res. 2001;  33 423-427
• 25 Chicharro J L, Hoyos J, Bandres F, Terrados N, Fernandez B, Lucia A. Thyroid hormone levels during a 3-week professional road cycling competition.  Horm Res. 2001;  56 159-164
• 26 Thong F S, McLean C, Graham T E. Plasma leptin in female athletes: relationship with body fat, reproductive, nutritional, and endocrine factors.  J Appl Physiol. 2000;  88 2037-2044
• 27 Loucks A B, Laughlin G A, Mortola J F, Girton L, Nelson J C, Yen S S. Hypothalamic-pituitary-thyroidal function in eumenorrheic and amenorrheic athletes.  J Clin Endocrinol Metab. 1992;  75 514-518
• 28 Alen M, Pakarinen A, Hakkinen K. Effects of prolonged training on serum thyrotropin and thyroid hormones in elite strength athletes.  J Sports Sci. 1993;  11 493-497