Menin Molecular Interactions: Insights into Normal Functions and Tumorigenesis

S. K. Agarwal; P. A. Kennedy; P. C. Scacheri; E. A. Novotny; A. B. Hickman; A. Cerrato; T. S. Rice; J. B. Moore; S. Rao; Y. Ji; C. Mateo; S. K. Libutti; B. Oliver; S. C. Chandrasekharappa; A. L. Burns; F. S. Collins; A. M. Spiegel; S. J. Marx

doi:10.1055/s-2005-870139

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 2005; 37(6): 369-374
DOI: 10.1055/s-2005-870139

Review

Menin Molecular Interactions: Insights into Normal Functions and Tumorigenesis

S. K. Agarwal¹ , P. A. Kennedy¹ , P. C. Scacheri² , E. A. Novotny² , A. B. Hickman¹ , A. Cerrato¹ , T. S. Rice¹ , J. B. Moore¹ , S. Rao¹ , Y. Ji² , C. Mateo¹ , S. K. Libutti³ , B. Oliver¹ , S. C. Chandrasekharappa² , A. L. Burns¹ , F. S. Collins² , A. M. Spiegel⁴ , S. J. Marx¹

¹National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA
²National Human Genome Research Institute, NIH, Bethesda, MD, USA
³National Cancer Institute, NIH, Bethesda, MD, USA
⁴National Institute of Deafness and Communication Disorders, NIH, Bethesda, MD, USA

Abstract

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disease predisposed by heterozygous germline mutations in the MEN1 tumor suppressor gene. Biallelic loss of MEN1 resulting from small mutation and/or loss of heterozygosity occurs in a large tissue spectrum of MEN1 tumors or non-hereditary tumors. Mouse models of MEN1 underexpression or overexpression have also supported the tumor-suppressor effect of the MEN1 gene. Menin, the 610-amino-acid protein encoded by MEN1, is expressed ubiquitously and found predominantly in the nucleus. Sequence analyses do not reveal motifs of known function other than two nuclear localization sequences. Menin has been found to partner in vitro with a variety of proteins that comprise transcription factors, DNA processing factors, DNA repair proteins, and cytoskeletal proteins. The diverse functions of menin interactors suggest roles for menin in multiple biological pathways. Inactivation of menin switches its JunD partner from a downstream action of growth suppression to growth promotion. This is a plausible mechanism for menin tumorigenesis.

Key words

MEN1 - JunD - MLL - Hox genes - Tumor suppressor - Oncogene - Multiple endocrine neoplasia - Transcription - Partners

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Referenzen

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