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Synfacts 2005(0): 0038-0038  
DOI: 10.1055/s-2005-869940
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Base-Free Asymmetric Transfer Hydrogenation of Aromatic Ketones

Contributor(s): Mark Lautens, Josephine Yuen
Z.-R. Dong, Y.-Y. Li, J.-S. Chen, B.-Z. Li, Y. Xing, J.-X. Gao*
Xiamen University, P. R. China
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Publication History

Publication Date:
20 July 2005 (online)

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Significance

A highly enantioselective hydrogenation of aromatic ketones using IrH(CO)(PPh3)3 and a tetradentate PNNP-type ligand is described. The ability to perform the reaction in the absence of base allows a wider substrate scope. A variety of other ligands (binary and PNNP-type) and metal hydride complexes were investigated.