Download PDF
Synfacts 2005(0): 0042-0042  
DOI: 10.1055/s-2005-869920
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

‘One-Pot’ Zr-Catalyzed Asymmetric Carboalumination-Pd Cross-Coupling

Contributor(s): Hisashi Yamamoto, Matthew Boxer
T. Novak, Z. Tan, B. Liang, E. Negishi*
Purdue University, West Lafayette, USA
Further Information

Publication History

Publication Date:
20 July 2005 (online)

   Permissions and Reprints

Significance

An efficient all-catalytic asymmetric protocol for the synthesis of α,ω-diheterofunctional reduced polypropionates in one pot has been achieved. Starting from inexpensive styrene, asymmetric Zr-catalyzed carbo-alumination followed by Pd-catalyzed vinylation of the isoalkyl­alanes allows for the construction of reduced polypropionate chains.