Synlett 2005(12): 1897-1900  
DOI: 10.1055/s-2005-869875
LETTER
© Georg Thieme Verlag Stuttgart · New York

Efficient Pd(OAc)2/Pyrimidine Catalytic System for Suzuki-Miyaura Cross-Coupling Reaction

Jin-Heng Li*, Xu-Dong Zhang, Ye-Xiang Xie
Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, P. R. China
Fax: +86(731)8872531; e-Mail: jhli@hunnu.edu.cn;
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Publikationsverlauf

Received 27 April 2005
Publikationsdatum:
04. Juli 2005 (online)

Abstract

A combination of Pd(OAc)2 and 2-aminopyrimidine-4,6-diol was found to be a stable and efficient catalytic system for the Suzuki-Miyaura cross-coupling of aryl halides with arylboronic acids. In the presence of Pd(OAc)2 and 2-aminopyrimidine-4,6-­diol, various ArX (X = I, Br, and Cl) were coupled with arylboronic acids efficiently to afford the corresponding cross-coupled products in moderate to excellent yields. Furthermore, high turnover numbers (up to 1000000 for the reaction of iodobenzene with phenyl­boronic acid) for the palladium-catalyzed Suzuki-Miyaura cross-coupling reaction were observed.