Semin Respir Crit Care Med 2005; 26(2): 204-210
DOI: 10.1055/s-2005-869539
Copyright © 2005 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Epidemiology and Global Impact of Chronic Obstructive Pulmonary Disease

David M. Mannino1
  • 1Division of Pulmonary and Critical Care Medicine, University of Kentucky School of Medicine, Lexington, Kentucky
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
27. April 2005 (online)

ABSTRACT

Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease that causes a heavy health and increasing economic burden both in the United States and around the world. Most of the risk factors for COPD are well known and include smoking, occupational exposures, air pollution, airway hyperresponsiveness, asthma, and certain genetic variations, although many questions, such as why a minority of smokers develop significant airway obstruction, remain. Major medical organizations have agreed on a common definition of COPD, although newer measures, such as functional status or exercise capability, have emerged as important in determining the prognosis of COPD patients. In most of the world, COPD prevalence and mortality are still increasing and will likely continue to rise in response to increases in smoking, particularly by women and adolescents. Resources aimed at smoking cessation and prevention, COPD education and early detection, and better treatment will be of the most benefit in our continuing efforts against this important cause of morbidity and mortality.

REFERENCES

  • 1 Pauwels R A, Buist A S, Calverley P M, Jenkins C R, Hurd S S. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) workshop summary.  Am J Respir Crit Care Med. 2001;  163 1256-1276
  • 2 Celli B R, MacNee W. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper.  Eur Respir J. 2004;  23 932-946
  • 3 Mannino D M. COPD: epidemiology, prevalence, morbidity and mortality, and disease heterogeneity.  Chest. 2002;  121 121S-126S
  • 4 Doll R, Peto R, Boreham J, Sutherland I. Mortality in relation to smoking: 50 years' observations on male British doctors.  BMJ. 2004;  328 1519-1528
  • 5 Trupin L, Earnest G, San Pedro M et al.. The occupational burden of chronic obstructive pulmonary disease.  Eur Respir J. 2003;  22 462-469
  • 6 Smith K R, Mehta S. The burden of disease from indoor air pollution in developing countries: comparison of estimates.  Int J Hyg Environ Health. 2003;  206 279-289
  • 7 Romieu I, Trenga C. Diet and obstructive lung diseases.  Epidemiol Rev. 2001;  23 268-287
  • 8 Shaheen S O, Barker D J, Holgate S T. Do lower respiratory tract infections in early childhood cause chronic obstructive pulmonary disease?.  Am J Respir Crit Care Med. 1995;  151 1649-1651
  • 9 Silverman E K, Speizer F E. Risk factors for the development of chronic obstructive pulmonary disease.  Med Clin North Am. 1996;  80 501-522
  • 10 Mayer A S, Newman L S. Genetic and environmental modulation of chronic obstructive pulmonary disease.  Respir Physiol. 2001;  128 3-11
  • 11 Lomas D A, Silverman E K. The genetics of chronic obstructive pulmonary disease.  Respir Res. 2001;  2 20-26
  • 12 O'Byrne P M, Postma D S. The many faces of airway inflammation: asthma and chronic obstructive pulmonary disease. Asthma Research Group.  Am J Respir Crit Care Med. 1999;  159 S41-S63
  • 13 Sparrow D, O'Connor G, Weiss S T. The relation of airways responsiveness and atopy to the development of chronic obstructive lung disease.  Epidemiol Rev. 1988;  10 29-47
  • 14 Ulrik C S, Backer V. Nonreversible airflow obstruction in life-long nonsmokers with moderate to severe asthma.  Eur Respir J. 1999;  14 892-896
  • 15 Meyer P A, Mannino D M, Redd S C, Olson D R. Characteristics of adults dying with COPD.  Chest. 2002;  122 2003-2008
  • 16 World Health Organization .The GOLD global strategy for the management and prevention of COPD. http://Available at: www.goldcopd.com Accessed April 5, 2005
  • 17 Celli B R, Halbert R J, Isonaka S, Schau B. Population impact of different definitions of airway obstruction.  Eur Respir J. 2003;  22 268-273
  • 18 Kohler D, Fischer J, Raschke F, Schonhofer B. Usefulness of GOLD classification of COPD severity.  Thorax. 2003;  58 825
  • 19 Dirksen A, Christensen H, Evald T et al.. Bronchodilator and corticosteroid reversibility in ambulatory patients with airways obstruction.  Dan Med Bull. 1991;  38 486-489
  • 20 Bestall J C, Paul E A, Garrod R, Garnham R, Jones P W, Wedzicha J A. Usefulness of the Medical Research Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease.  Thorax. 1999;  54 581-586
  • 21 Celli B R, Cote C G, Marin J M et al.. The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease.  N Engl J Med. 2004;  350 1005-1012
  • 22 American Thoracic Society . Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease.  Am J Respir Crit Care Med. 1995;  5 S77-S121
  • 23 Snider G L. Chronic obstructive pulmonary disease: a definition and implications of structural determinants of airflow obstruction for epidemiology.  Am Rev Respir Dis. 1989;  140(suppl 3) S3-S8
  • 24 National Emphysema Treatment Trial Research Group . Patients at high risk of death after lung-volume-reduction surgery.  N Engl J Med. 2001;  345 1075-1083
  • 25 Sheffer A L, Taggart V S. The National Asthma Education Program. Expert panel report guidelines for the diagnosis and management of asthma. National Heart, Lung, and Blood Institute.  Medical Care. 1993;  31(suppl 3) MS20-28
  • 26 Mannino D M, Gagnon R C, Petty T L, Lydick E. Obstructive lung disease and low lung function in adults in the United States: data from the National Health and Nutrition Examination Survey, 1988-1994.  Arch Intern Med. 2000;  160 1683-1689
  • 27 Soriano J B, Davis K J, Coleman B, Visick G, Mannino D, Pride N B. The proportional Venn diagram of obstructive lung disease: two approximations from the United States and the United Kingdom.  Chest. 2003;  124 474-481
  • 28 Sharp D S, Burchfiel C M, Curb J D, Rodriguez B L, Enright P L. The synergy of low lung function and low body mass index predicting all-cause mortality among older Japanese-American men.  J Am Geriatr Soc. 1997;  45 1464-1471
  • 29 Wouters E F, Creutzberg E C, Schols A M. Systemic effects in COPD.  Chest. 2002;  121 127S-130S
  • 30 Bowen J B, Votto J J, Thrall R S et al.. Functional status and survival following pulmonary rehabilitation.  Chest. 2000;  118 697-703
  • 31 Ferrer M, Villasante C, Alonso J et al.. Interpretation of quality of life scores from the St George's Respiratory Questionnaire.  Eur Respir J. 2002;  19 405-413
  • 32 Agusti A G. Systemic effects of chronic obstructive pulmonary disease.  Novartis Found Symp. 2001;  234 242-249
  • 33 Eisner M D, Yelin E H, Trupin L, Blanc P D. The influence of chronic respiratory conditions on health status and work disability.  Am J Public Health. 2002;  92 1506-1513
  • 34 Yohannes A, Baldwin R, Connolly M. Depression and anxiety in elderly outpatients with chronic obstructive pulmonary disease: prevalence, and validation of the BASDEC screening questionnaire.  Int J Geriatr Psychiatry. 2000;  15 1090-1096
  • 35 Upshur R E, Knight K, Goel V. Time-series analysis of the relation between influenza virus and hospital admissions of the elderly in Ontario, Canada, for pneumonia, chronic lung disease, and congestive heart failure.  Am J Epidemiol. 1999;  149 85-92
  • 36 National Center for Health Statistics . National Health Interview Survey: research for the 1995-2004 redesign.  Vital Health Stat. 1999;  2 1-119
  • 37 Mannino D M, Homa D M, Akinbami L, Ford E S, Redd S C. Surveillance for Chronic Obstructive Pulmonary Disease: United States, 1971-2000.  MMWR Surveill Summ. 2002; 
  • 38 Plan and operation of the Third National Health and Nutrition Examination Survey, 1988-94. Series 1: programs and collection procedures.  Vital Health Stat. 1994;  32 1-407
  • 39 Standardization of spirometry-1987 update: statement of the American Thoracic Society.  Am Rev Respir Dis. 1987;  136 1285-1298
  • 40 Kanner R E, Connett J E, Altose M D et al.. Gender difference in airway hyperresponsiveness in smokers with mild COPD. The Lung Health Study.  Am J Respir Crit Care Med. 1994;  150 956-961
  • 41 Enright P L, Johnson L R, Connett J E, Voelker H, Buist A S. Spirometry in the Lung Health Study, I: Methods and quality control.  Am Rev Respir Dis. 1991;  143 1215-1223
  • 42 Chang J T, Moran M B, Cugell D W, Webster Jr J R. COPD in the elderly: a reversible cause of functional impairment.  Chest. 1995;  108 736-740
  • 43 Halbert R J, Isonaka S, George D, Iqbal A. Interpreting COPD prevalence estimates: what is the true burden of disease?.  Chest. 2003;  123 1684-1692
  • 44 Mannino D M, Buist A S, Petty T L, Enright P L, Redd S C. Lung function and mortality in the United States: data from the First National Health and Nutrition Examination Survey follow-up study.  Thorax. 2003;  58 388-393
  • 45 Mannino D M, Ford E S, Redd S C. Obstructive and restrictive lung disease and functional limitation: data from the Third National Health and Nutrition Examination.  J Intern Med. 2003;  254 540-547
  • 46 Slusarcick A L, McCaig L F. National Hospital Ambulatory Medical Care Survey: 1998 outpatient department summary.  Adv Data. 2000;  317 1-23
  • 47 McCaig L F. National Hospital Ambulatory Medical Care Survey: 1998 emergency department summary.  Adv Data. 2000;  313 1-23
  • 48 Dennison C, Pokras R. Design and operation of the National Hospital Discharge Survey: 1988 redesign.  Vital Health Stat. 2000;  1 1-42
  • 49 Popovic J R, Kozak L J. National hospital discharge survey: annual summary, 1998.  Vital Health Stat. 2000;  13 1-194
  • 50 Murphy S L. Deaths: Final data for 1998.  Natl Vital Stat Rep. 2000;  48 1-106
  • 51 Mannino D M, Brown C, Giovino G A. Obstructive lung disease deaths in the United States from 1979 through 1993: an analysis using multiple-cause mortality data.  Am J Respir Crit Care Med. 1997;  156 814-818
  • 52 Camilli A E, Robbins D R, Lebowitz M D. Death certificate reporting of confirmed airways obstructive disease.  Am J Epidemiol. 1991;  133 795-800
  • 53 Sullivan S D, Ramsey S D, Lee T A. The economic burden of COPD.  Chest. 2000;  117 5S-9S
  • 54 National Heart Lung and Blood Institute .Chronic Obstructive Pulmonary Disease. Available at: http://www.nhlbi.nih.gov/health/public/lung/other/copd_fact.pdf Accessed April 6, 2005
  • 55 Wouters E F. Economic analysis of the Confronting COPD survey: an overview of results.  Respir Med. 2003;  97(suppl C) S3-S14
  • 56 Halpern M T, Stanford R H, Borker R. The burden of COPD in the U.S.A.: results from the Confronting COPD survey.  Respir Med. 2003;  97(suppl C) S81-S89
  • 57 Michaud C M, Murray C J, Bloom B R. Burden of disease: implications for future research.  JAMA. 2001;  285 535-539
  • 58 Lopez A D, Murray C C. The global burden of disease, 1990-2020.  Nat Med. 1998;  4 1241-1243

David M ManninoM.D. 

Division of Pulmonary and Critical Care Medicine, University of Kentucky School of Medicine

800 Rose St., MN 614, Lexington, KY 40536

eMail: dmmann2@email.uky.edu