Quetiapin in der Behandlung der akuten Manie

Zusammenfassung

Quetiapin ist ein atypisches Neuroleptikum, das sowohl Positiv- als auch Negativsymptome schizophrener Erkrankungen günstig beeinflusst, ohne extrapyramidalmotorische Nebenwirkungen auszulösen oder die Kognition ungünstig zu beeinflussen. Es gibt mittlerweile mehrere plazebokontrollierte, doppelblinde Studien, Fallberichte und offene Studien zum Einsatz von Quetiapin bei akuten Manien und therapierefraktären bipolaren Erkrankungen bei veschiedenen Patientengruppen. Insgesamt scheint Quetiapin stimmungsstabilisierende Eigenschaften bei einem günstigen Verträglichkeitsprofil zu haben.

Abstract

Quetiapine is an atypical antipsychotic that has shown efficacy in the treatment of positive and negative symptoms in schizophrenia without causing extrapyramidal symptoms (EPS). To date, there are two monotherapy and two combination therapy studies with a double blind, placebo-controlled design on the use of quetiapine in mania. Several open studies and case reports support the results of the controlled trials suggesting that quetiapine is effective in treating the broad spectrum of manic symptoms and is tolerated well.

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