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Synfacts 2005(0): 0012-0012
DOI: 10.1055/s-2005-865348
DOI: 10.1055/s-2005-865348
Synthesis of Natural Products and Drugs
© Georg Thieme Verlag Stuttgart · New York
Total Synthesis of (-)-Agelastatin
F. A. Davis*, J. Deng
Temple University, Philadelphia, USA
Further Information
Publication History
Publication Date:
20 July 2005 (online)
Significance
The target molecule was isolated from the sponge Agelas dedromorpha. It is active against several tumour cell lines and it inhibits glycogen synthase kinase-3β. It has potential for the treatment of Alzheimer’s disease, the prevention of neuronal apoptosis after stroke and it could function as an insulin mimetic.