Lippia dulcis Trevis

Zusammenfassung

Die weltweite Suche nach neuen Süßungsmitteln für diätetische Zubereitungen und Arzneimittel konzentriert sich neben synthetischen Verbindungen auch auf pflanzliche Naturstoffe. Ein interessantes Beispiel dafür ist die Verbenaceae Lippia dulcis Trevis., Aztekisches Süßkraut, die das Sesquiterpen (+)-Hernandulcin enthält. Es hat die etwa 1000fache Süßkraft von Saccharose. Die Pflanze besitzt eine lange therapeutische Tradition bei der Behandlung von Husten, Bronchitis und Koliken. Eine Neubewertung von Lippia dulcis als Süßstoffpflanze bzw. als Arzneipflanze zur Behandlung von Erkältungskrankheiten erscheint lohnenswert.

Summary

Lippia dulcis Trevis. - an Aztecan sweet herb of potential interest.

The demand for new alternative »low calorie«-sweeteners for dietetic and diabetic purposes has increased worldwide. On one hand, the current commercial sources of highly sweet sucrose substitutes are mostly synthetic compounds (e.g. saccharin, aspartame). On the other hand, the search for such compounds from natural sources is continuing and some natural products are used, e.g. stevioside (diterpene), glycyrrhizin (triterpenoid saponin) or thaumatin (protein). Recent progress in research oriented towards the discovery and evaluation of potentially non-cariogenic sweeteners from plants has focused on terpenoid substances. An interesting example is Lippia dulcis Trevis., a Verbenaceae from Central America containing sesquiterpenoid sweeteners in the essential oil like (+)-hernandulcin and 4β-hydroxyhernandulcin which are 1000 times sweeter than sucrose. The name Aztec Sweet Herb points to the fact that the plant has been used for a long time in traditional medicine especially for the treatment of coughs, colds, bronchitis, asthma, and colic. Due to the sweet taste, the composition of the essential oil, and other natural products in the extract, the plant might be of interest for use in herbal remedies as a sweetener or for treating common colds.

Lippia dulcis Trevis. - sweetener - natural products - traditional medicine

Literatur

• 1 Abe F, Nagao T, Okabe H. Antiproliferative constituents in plants. 9. Aerial Parts of Lippia dulcis and Lippia canescens .  Biol Pharm Bull. 2002;  25 920-922
• 2 Breitwieser K. The Verbenaceae of the German drug trade.  Pharm Ind. 1943;  10 76-78
• 3 Burghart J. Lippia . in: Hänsel R, Keller LK, Rimpler H, Schneider G (Hrsg.): Hagers Handbuch der Pharmazeutischen Praxis Berlin; Springer 1993 5: 686-688
• 4 Caceres A, Alvarez AV, Ovando AE, Samayoa BE. Plants used in Guatemala for the treatment of respiratory diseases. 1. Screening of 68 plants against gram-positive bacteria.  J Ethnopharmacol. 1991;  31 192-208
• 5 Caceres A, Fletes L, Aguilar L. Plants used in Guatemala for the treatment of gastrointestinal disorders. 3. Confirmation of activity against enterobacteria of 16 plants.  J Ethnopharmacol. 1993;  38 31-38
• 6 Compadre CM, Pezzuto JM, Kinghorn AD, Kamath SK. Hernandulcin: an intensely sweet compound discovered by review of ancient literature.  Science. 1985;  227 417-419
• 7 Compadre CM, Robbins EF, Kinghorn AD. The intensely sweet herb, Lippia dulcis Trev.: historical uses, field inquiries, and constituents.  J Ethnopharmacol. 1986;  15 89-106
• 8 Compadre CM, Hussain RA, Lopez de Compadre RL, Pezzuto JM, Kinghorn AD. The intensely sweet sesquiterpene Hernandulcin: Isolation, synthesis, characterization, and preliminary safety evaluation.  J Agric Food Chem. 1987;  35 273-279
• 9 Compadre CM, Hussain RA, Lopez de Compadre RL, Pezzuto JM, Kinghorn AD. Potential sweetening agents of plant origin. 14. Analysis of structural features responsible for the sweetness of the sesquiterpene hernandulcin.  Experientia. 1988;  44 447-449
• 10 Craveiro AA, Alencar JW, Matos FJA, Andrade CHS, Machado MIL. Essential oils from Brazilian Verbenaceae. Genus Lippia .  J Nat Prod. 1981;  44 598-601
• 11 Davis GS. Organic Materia Medica.  2 Detroit; Parke-Davis 1890: 115
• 12 Dellacassa A, Soler E, Menendez P, Moyna P. Essential oils from Lippia alba (Mill.) N.E.Brown and Aloysia chamaedrifolia Cham. (Verbenaceae) from Uruguay.  Flavour Fragrance J. 1990;  5 503-506
• 13 Duffy VB, Anderson GH. Position of the American Dietetic Association: use of nutritive and non-nutritive sweeteners.  J Am Dietet Assoc. 1998;  98 580-587
• 14 Gibson DN. Lippia . in: Standley PC, Williams LO, Gibson DN (eds.): Flora of Guatemala. Fieldiana-Botany 1970 24: 206-216
• 15 Gomi T. Dentifrices and mouthwashes containing menthol and Lippia dulcis essential oil.  Jpn Kokai Tokkyo Koho. 1992; 
• 16 Guevara JM, Chumpitaz J, Valencia E. The in vitro action of plants on Vibrio cholerae .  Rev Gastroenterol Peru. 1994;  14 27-31
• 17 Hernandez F. Rerum Medicarum Novae Hispaniae Thesaurus seu Plantarum, Animalium, Mineralium Mexicanorum Historia. Rome; Typographeio Vitalis Mascardi 1651: 240
• 18 Kaneda N, Lee IS, Gupta MP, Soejarto DD, Kinghorn AD. (+)-4 beta-hydroxyhernandulcin, an new sweet sesquiterpene from the leaves and flowers of Lippa dulcis .  J Nat Prod. 1992;  55 1136-1141
• 19 Kim NC, Kinghorn AD. Highly sweet compounds of plant origin.  Arch Pharm Res. 2002;  25 725-746
• 20 Kinghorn AD, Compadre CM, Pezzuto JM. U.S. Patent. 1989; 
• 21 Kinghorn AD, Fullas F, Hussain RA. Structure-activity relationship of highly sweet natural products. In: Atta-ur-Rahman (ed.): Studies in Natural Products Chemistry Amsterdam; Elsevier 1995: 3-41
• 22 Kinghorn AD, Kennelly EJ. Discovery of highly sweet compounds from natural sources.  J Chem Educ. 1995;  72 676
• 23 Kinghorn AD, Kaneda N, Baek NI, Kennelly EJ, Soerjarto DD. Noncariogenic intense natural sweeteners.  Med Res Rev. 1998;  18 347-360
• 24 Kinghorn AD, Soejarto DD. Discovery of terpenoid and phenolic sweeteners from plants.  Pure Appl Chem. 2002;  74 1169-1179
• 25 Liogier HA, Martorell LF. Flora of Puerto Rico and Adjacent Islands: A Systematic Synopsis. Puerto Rico; Rio Piedras 1982: 153
• 26 Martinez M. Las Plantas Medicinales de Mexico.  5 Mexico; Ediciones Botas 1969: 166
• 27 Morton J. Atlas of Medicinal Plants of Middle America: Bahamas to Yucatan. New York; CC Thomas 1981: 746
• 28 Nunez-Melendez E. Plantas Medicinales de Puerto Rico: Folklore y Fundamentos Cientirficos. Puerto Rico; Rio Piedras 1989: 204
• 29 Sayre JK. Ancient Herbs and Modern Herbs. San Carlos Calif; Bottlebrush Press 2001
• 30 Sauerwein M, Flores HE, Yamazaki T, Shimomura K. Lippia dulcis shoot cultures as a source of the sweet sesquiterpene hernandulcin.  Plant Cell Reports. 1991;  9 663-666
• 31 Souto Bachiller FA, De Jesus-Echevarria M, Cardenas-Gonzalez OE. Hernandulcin is the major constituent of Lippia dulcis .  Natural Products Letters. 1996;  8 151-158
• 32 Souto Bachiller FA, De Jesus-Echevarria M, Cardenas-Gonzalez OE. Terpenoid composition of Lippia dulcis .  Phytochemistry. 1997;  44 1077-1086
• 33 Standley PC. Flora of the Panama Canal Zone. Contributions from the U.S. National Herbarium. Smithsonian Institution. Washington D.C.; U.S. Government Printing Office 27 1928: 324
• 34 Tanaka O. Improvement of taste of natural sweeteners.  Pure Appl Chem. 1997;  69 675-683
• 35 Vamdaveer C. What is the Aztec sweet herb?.  http://www.killerplants.com/weird-plants/20031204.asp
• 36 Watson L, Dallwitz MJ. The families of flowering plants: descriptions, illustrations, identification and information retrieval.  http://florawww.eeb.uconn.edu/acc_num/198900074.html
• 37 Wren RW. Potter’s New Encyclopedia of Botanical Drugs and Preparations.  7 Essex; Saffron Walden 1970: 186

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