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Synlett 2005(6): 0943-0946  
DOI: 10.1055/s-2005-864809
LETTER
© Georg Thieme Verlag Stuttgart · New York

Efficient One-Pot Synthesis of 1,2,3-Triazoles from Benzyl and Alkyl Halides

Karol Kacprzak*
Department of Chemistry, Adam Mickiewicz University, ul. Grunwaldzka 6, 60-780 Poznań, Poland
Fax: +48(61)8658008; e-Mail: k.michal@mailcity.com;
Further Information

Publication History

Received 21 December 2004
Publication Date:
23 March 2005 (online)

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Abstract

An efficient one-pot method for the preparation of 1,2,3-triazoles by 1,3-dipolar cycloaddition of in situ generated azides and alkynes is presented. This facile method can be applied to benzyl or alkyl halides and pure products are isolated by simple filtration.

Key words

1,3-dipolar cycloadditon - click chemistry - 1,2,3-tri­azoles - one-pot synthesis

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Progress of the reaction can be monitored by TLC.