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Semin Thromb Hemost 2005; 31(1): 97-103
DOI: 10.1055/s-2005-863811
Copyright © 2005 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Thrombophilia Related Issues in Women and Children

Ron Hoffman1 , 2 , Benjamin Brenner2
  • 1Head of Inpatient Hematology Unit, Department of Hematology and Bone Marrow Transplantation, Rambam Medical Center, Bruce Rappaport Faculty of Medicine Haifa, Israel
  • 2Thrombosis & Hemostasis Unit, Department of Hematology and Bone Marrow Transplantation, Rambam Medical Center, Bruce Rappaport Faculty of Medicine Haifa, Israel
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Publikationsverlauf

Publikationsdatum:
11. Februar 2005 (online)

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ABSTRACT

Women experience increased thrombotic risk at pregnancy and puerperium as well as during hormonal therapy with oral contraceptives or hormone replacement therapy. Physiological and anatomical changes in pregnancy contribute to the hypercoagulable situation. Women with thrombophilia have an increased risk for venous and arterial thromboembolism as well as for gestational vascular complications including fetal loss, pre-eclampsia, placental abruption, and fetal growth restriction. Children are at increased thrombotic risk, particularly at the neonatal period, and may express thrombosis often in association with thrombophilia. This article will focuses on the clinical association, pathogenesis, and treatment of thrombophilia-related issues in women and children.

KEYWORDS

Pregnancy - thrombophilia - gestational complications - thrombosis - hormonal therapy

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B. BrennerM.D. 

Department of Hematology and Bone Marrow Transplantation

Rambam Medical Center, Haifa 31096, Israel

eMail: b_brenner@rambam.health.gov.il