Synlett 2005(3): 538-540  
DOI: 10.1055/s-2005-862367
LETTER
© Georg Thieme Verlag Stuttgart · New York

Microwave Assisted Suzuki Reactions for the Preparation of the Antifungal 3-Aryl-5-methyl-2,5-dihydrofuran-2-ones

Christopher J. Mathews, John Taylor, Melloney J. Tyte, Paul A. Worthington*
Syngenta, Jealott’s Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK
Fax: +44(1344)455629; e-Mail: paul.worthington@syngenta.com;
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Publikationsverlauf

Received 14 December 2004
Publikationsdatum:
04. Februar 2005 (online)

Abstract

The Suzuki cross-coupling reaction of arylboronic acids with a bromo-furanone has been developed to prepare a series of substituted 2,5-dihydrofuran-2-ones related to the fungal metabolite, incrustoporin. A protocol of microwave heating was introduced to improve synthesis throughput.

14

An automated SmithCreatorTM microwave system was used (purchased from Personal Chemistry).