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DOI: 10.1055/s-2005-861296
The Effect of Short-term Cold and Hot Exposure on Total Plasma Ghrelin Concentrations in Humans
Publication History
Received 2 June 2004
Accepted after revision 10 November 2004
Publication Date:
12 April 2005 (online)
Introduction
Ghrelin is one of the peptides involved in the gut-brain axis. This 28-aminoacid peptide is primarily produced in the stomach and small intestine [1]. The first role of ghrelin to be determined involved the release of growth hormone [2], but later, the focus was placed on the role of this peptide in eating behavior and weight regulation [3] [4]. Ghrelin is upregulated during fasting; suggestions have been made that ghrelin is a signal of meal initiation [5]. Ambient temperature has been known to be a powerful metabolic regulator since the forties - a high environmental temperature results in decreased food intake, while a low environmental temperature leads to increased food intake [6]; however, the regulatory mechanism responsible for this phenomenon is still unclear. Therefore, the aim of this study was to investigate the relationship between plasma ghrelin levels and environmental temperature.
References
- 1 Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Nature. 2000; 400 661-671
- 2 Pombo M, Pombo C M, Garcia A, Caminos E, Gualillo O, Alvarez C V, Casanueva F F, Dieguez C. Horm Res. 2001; 55 Suppl 1 1-16
- 3 Bizzarri C, Rigamonti A E, Giannone G, Berardinelli R, Cella S G, Cappa M, Muller E E. Horm Metab Res. 2004; 36 164-169
- 4 Ott V, Fasshauer M, Dalski A, Meier B, Perwitz N, Klein H H, Tschop M, Klein J. Horm Metab Res. 2002; 34 640-645
- 5 Cummings D E, Purnell J Q, Frayo R S, Schmidova K, Wisse B E, Weigle D S. Diabetes. 2001; 50 1714-1719
- 6 Brobeck J R. 1948 (classical article) Obesity Research. 1997; 5 641-645
- 7 Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S. Nature. 2001; 409 194-198
- 8 Nagaya N, Uematsu M, Kojima M, Date Y, Nakazato M, Okumura H, Hosoda H, Shimizu W, Yamagishi M, Oya H, Koh H, Yutani C, Kangawa K. Circulation. 2001; 104 2034-2038
- 9 Wren A M, Seal L J, Cohen M A, Brynes A E, Frost G S, Murphy K G, Dhillo W S, Ghatei M A, Bloom S R. J Clin Endocrinol Metab. 2001; 86 5992-5995
- 10 Bjerkedal T, Beckstrom J R, Brevik J I, Skaden K. Tidsskrift for Den Norske Laegeforening. 2001; 121 674-677
- 11 Meyer H E, Falach J A, O'Neill T, Tverdal A, Varlow J. Bone. 1995; 17 347-350
- 12 Lucidi P, Murdolo G, di Loreto C, Parlanti N, de Cicco A, Ranchelli A, Fatone C, Taglioni C, Fanelli C, Santeusanio F, De Feo P. J Endocrinol Invest. 2004; 27 RC12-15
Dr. Przemyslaw J. Tomasik
Department of Clinical Biochemistry · University Children’s Hospital ·
Wielicka St. 265 · 30663 Krakow · Poland
Fax: +48 (12) 658 06 81
Email: mitomasi@cyf-kr.edu.pl