RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000131.xml
Synfacts 2006(1): 0006-0006
DOI: 10.1055/s-2005-621659
DOI: 10.1055/s-2005-621659
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of (-)-Epibatidine
T.-P. Loh*, C.-L. K. Lee
Nanyang Technical University, Singapore
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
16. Dezember 2005 (online)
Significance
(-)-Epibatidine, an alkaloid isolated from the Ecuadorian dendrobatid poison frog Epipedobates tricolor, is a nonopiate analgesic 200 times more potent than morphine. The scarcity of (-)-Epibatidine (1 mg from 750 frogs) has hampered its biological evaluation. There are many syntheses of Epibatidine but few of them are practical. The present synthesis is short (12 steps, 12% overall yield) and scalable.