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Semin Musculoskelet Radiol 2004; 08(4): 355-368
DOI: 10.1055/s-2004-861764
Copyright © 2004 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001 USA.

Cartilage MRI T2 Relaxation Time Mapping: Overview and Applications

Timothy J. Mosher1 , Bernard J. Dardzinski2 , 3 , 4
  • 1Department of Radiology, The Penn State Milton S. Hershey Medical Center, Hershey Pennsylvania
  • 2Imaging Research Center, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
  • 3Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, Ohio
  • 4Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio
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Publikationsdatum:
10. Januar 2005 (online)

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ABSTRACT

The sensitivity of magnetic resonance imaging to biochemical and biophysical changes in the extracellular matrix of articular cartilage give it the potential to noninvasively detect the earliest changes of cartilage damage. The transverse relaxation time (T2) of cartilage has been shown to be a sensitive parameter for evaluation of early degeneration in articular cartilage, particularly changes in water and collagen content and tissue anisotropy. Although initial application has been in microimaging of small cartilage explants, in vivo techniques have been developed for cartilage T2 mapping of human joints. In addition to potential application in development of new pharmaceuticals and surgical techniques for preserving cartilage, in vivo cartilage T2 mapping can improve understanding of arthritis, cartilage aging, and response of cartilage to exercise.

KEYWORDS

Articular cartilage - cartilage collagen - arthritis - osteoarthritis - magnetic resonance imaging - cartilage T2

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Timothy J MosherM.D. 

Department of Radiology/NMR Building M108

Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA 17033