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Synthesis 2005(3): 442-446
DOI: 10.1055/s-2004-837299
DOI: 10.1055/s-2004-837299
PAPER
© Georg Thieme Verlag Stuttgart · New York
A New Approach to the Synthesis of Tazobactam Using an Organosilver Compound
Weitere Informationen
Received
30 August 2004
Publikationsdatum:
22. Dezember 2004 (online)
Publikationsverlauf
Publikationsdatum:
22. Dezember 2004 (online)
![](https://www.thieme-connect.de/media/synthesis/200503/lookinside/thumbnails/10.1055-s-2004-837299-1.jpg)
Abstract
Tazobactam (9) was synthesized in 8 steps from the readily accessible 6-APA. By the first use of silver triazole as reactant, the formation of the isomer 7 was avoided and a total yield of 50%, which was two to three times higher than that of reported procedures for 9, was obtained.
Key words
synthesis - 6-APA - silver triazole - β-lactamase inhibitor - isomeric
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