Synlett 2004(15): 2681-2684  
DOI: 10.1055/s-2004-835629
LETTER
© Georg Thieme Verlag Stuttgart · New York

Efficient Synthesis of Novel Polyfunctionalised 4,5′-Bithiazol-4′-ol Derivatives

Antonio Arcadia, Orazio A. Attanasib, Paolino Filippone*b, Francesca R. Perrullib, Elisabetta Rossic, Stefania Santeusanio*b
a Dipartimento di Chimica, Ingegneria Chimica e dei Materiali della Facoltà di Scienze, Università de L’Aquila, Via Vetoio, Coppito Due, 67100 L’Aquila, Italy
b Istituto di Chimica Organica della Facoltà di Scienze Matematiche, Fisiche e Naturali, Università di Urbino ‘Carlo Bo’, Via Sasso 75, 61029 Urbino, Italy
c Istituto di Chimica Organica della Facoltà di Farmacia, Università di Milano, Via Venezian 21, 20139 Milano, Italy
Fax: +39(0722)303441; e-Mail: santeusanio@uniurb.it;
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Publikationsverlauf

Received 21 July 2004
Publikationsdatum:
08. November 2004 (online)

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Abstract

2-Thiazolin-4-one derivatives, obtained by reaction of tert-butyl (3-methoxy-1-methyl-3-oxoprop-1-enyl)diazenecarboxylate with aryl thioamides, were transformed into 5-bromoacetyl-4-hydroxythiazole derivatives by polymer-supported reagents and simple work-up procedures. The compounds thus synthesised were coupled with thioamides bearing valuable functional groups affording novel polyfunctionalised 4,5′-bithiazol-4′-ol derivatives.