Planta Med 2004; 70(10): 904-908
DOI: 10.1055/s-2004-832614
Original Paper
Pharmacology
© Georg Thieme Verlag KG Stuttgart · New York

Inhibition of Leukotriene Biosynthesis by Quinolone Alkaloids from the Fruits of Evodia rutaecarpa

Michael Adams1 , Olaf Kunert2 , Ernst Haslinger2 , Rudolf Bauer1
  • 1Institute of Pharmaceutical Sciences, Department of Pharmacognosy, Karl-Franzens-Universität Graz, Austria
  • 2Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Karl-Franzens-Universität Graz, Austria
Weitere Informationen

Publikationsverlauf

Received: April 20, 2004

Accepted: July 8, 2004

Publikationsdatum:
18. Oktober 2004 (online)

Abstract

The n-hexane extract of the fruits of Evodia rutaecarpa showed a considerable inhibiting effect on leukotriene biosynthesis in human granulocytes. Bioassay-guided fractionation of the extract led to the isolation of the 5 quinolone alkaloids: 1-methyl-2-nonyl-4(1H)-quinolinone, 1-methyl-2-(6Z)-6-undecenyl-4(1H)-quinolinone, 1-methyl-2-(4Z,7Z)-4,7-tridecadienyl-4(1H)-quinolinone, evocarpine and 1-methyl-2-(6Z,9Z)-6,9-pentadecadienyl-4(1H)-quinolinone. The compounds exhibited inhibitory activity on leukotriene biosynthesis in a bioassay using human polymorphonuclear granulocytes, with IC50 values of 12.1, 10.0, 10.1, 14,6 and 12.3 μM, respectively. Structure elucidation of the compounds was achieved by 1D and 2D NMR experiments and comparison of spectral data with literature data.

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Prof. Dr. Rudolf Bauer

Institute of Pharmaceutical Sciences

Department of Pharmacognosy

Karl-Franzens-Universität Graz

Universitätsplatz 4

8010 Graz

Austria

eMail: rudolf.bauer@uni-graz.at