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Semin intervent Radiol 2004; 21(1): 59-66
DOI: 10.1055/s-2004-831406
Copyright © 2004 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

The Use of Cyanoacrylate Adhesives in the Management of Congenital Vascular Malformations

Robert J. Rosen1 , 2 , Sohail Contractor2
  • 1Professor, Division of Interventional Radiology and Endovascular Surgery, New York University Medical Center, New York, New York
  • 2Division of Interventional Radiology and Endovascular Surgery, New York University Medical Center, New York, New York
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Publication History

Publication Date:
12 August 2004 (online)

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This article outlines the use of liquid acrylic adhesives in the management of congenital vascular malformations. Specifically, the chemical features of cyanoacrylates, including the physical and chemical properties, exovascular use of cyanoacrylates, and the techniques for use of these agents, are discussed.

KEYWORDS

Cyanoacrylates - vascular malformation - congenital disease

REFERENCES

  • 1 Kerber C W, Wong W. Liquid acrylic adhesive agents interventional Neuroradiology.  Neurosurg Clin N Am. 2000;  11 85-99
    PubMedGoogle Scholar
  • 2 Ardis A E. U.S. Patent 2,467,926, 1949. 
    Google Scholar
  • 3 Coover Jr H W, Joyner F B, Shearer Jr N H et al.. Chemistry and performance of cyanoacrylate adhesives.  Soc Plast Eng J. 1959;  15 413-417
    PubMedGoogle Scholar
  • 4 Barr J D, Hoffman E J, Davis B R, Edgar K A, Jacobs C R. Microcatheter adhesion of cyanoacrylates, comparison of normal butyl cyanoacrylate to 2-hexyl cyanoacrylate.  J Vasc Interv Radiol. 1999;  10 165-168
    PubMedGoogle Scholar
  • 5 The n-BCA trial investigators . AJNR Am J Neuroradiol. 2002;  23 748-755
    PubMed
  • 6 Schweitzer J S, Chang B S, Madsen P et al.. The pathology of arteriovenous malformations of the brain treated by embolotherapy.  Neuroradiology. 1993;  35 468-474
    CrossrefPubMedGoogle Scholar
  • 7 Toriumi D M, Raslan W F, Friedman M, Tardy M E. Histotoxicity of cyanoacrylate tissue adhesive: a comparative study.  Arch Otolaryngol Head Neck Surg. 1990;  116 546-550
    CrossrefPubMedGoogle Scholar
  • 8 Galil K A, Schonfield I D, Wright G Z. Effect of butyl 2-cyanoacrylate on the healing of skin wounds.  Can Dent Assoc J. 1984;  50 565-569
    PubMedGoogle Scholar
  • 9 Petrella E, Orlandini G, Poisetti P et al.. A new end to side anastomosis formed without sutures for hemodialysis fistulas.  Nephron. 1975;  14 398-400
    PubMedGoogle Scholar
  • 10 O'Leary J A. Tissue adhesives and pelvic hemostasis: an evaluation of isobutyl 2-cyanoacrylate.  J Surg Oncol. 1971;  3 117-120
    PubMedGoogle Scholar
  • 11 Fogle J A, Kenyon K R, Foster C S. Tissue adhesive arrests stromal melting in the human cornea.  Am J Ophthalmol. 1980;  89 795-802
    PubMedGoogle Scholar
  • 12 Wilkinson T S, Rybka F J. Experimental study of prevention of tip necrosis in ischemic z-plasties.  Plast Reconstr Surg. 1971;  47 37-38
    PubMedGoogle Scholar
  • 13 Smyth G DL, Kerr A G. Histoacryl (butyl cyanoacrylate) as an ossicular adhesive.  J Laryngol Otol. 1974;  88 539-542
    PubMedGoogle Scholar
  • 14 Bhaskar S N, Frisch J, Margetis P M, Leonard F. Application of a new chemical adhesive in periodontic and oral surgery.  Oral Surg. 1966;  22 526-535
    PubMedGoogle Scholar
  • 15 Bank W O, Kerber C W, Cromwell L D. Rapidly polymerizing glue for the treatment of intracerebral arteriovenous malformations. In: Moss A, Goldberg H Interventional Radiological Techniques: Computed Tomography and Ultrasonography. San Francisco; University of California Press 1981: 83-92
    Google Scholar
  • 16 Cromwell L D, Kerber C W. Modification of cyanoacrylate for therapeutic embolization: preliminary experience.  AMJ Am J Roentgenol. 1979;  132 799-801
    PubMedGoogle Scholar
  • 17 Spiegel S M, Vinuela F, Goldwasser J M, Fox A J, Pelz D M. Adjusting the polymerazation of isobutyl-2 cyanoacrylate.  AJNR Am J Neuroradiol. 1986;  7 109-112
    PubMedGoogle Scholar
  • 18 Sadato A, Wakhloo A K, Hopkins L N. Effect of a mixture of a Low concentration of n-butylcyanoacrylate and Ethiodol on tissue reactions and the permanence of arterial occlusion after embolization.  Neurosurgery. 2000;  47 1197-1203
    PubMedGoogle Scholar
  • 19 Brothers M F, Kaufman J C, Fox A J, Devekis J P. N-Butyl 2-cyanoacrylate- substitute for IBCA in interventional neuroradiology: histopathological and polymerization time studies.  AJNR Am J Neuroradiol. 1989;  10 777-786
    PubMedGoogle Scholar
  • 20 White Jr R I, Strandberg J V, Gross G S, Barth K H. Therapeutic embolization with long term occluding agents and their effects on embolized tissues.  Radiology. 1977;  125 677-687
    PubMedGoogle Scholar
  • 21 Vinters H V, Galil K A, Lundie M J, Kaufman J C. The histotoxicity of cyanoacrylates: a selective review.  Neuroradiology. 1985;  27 279-291
    CrossrefPubMedGoogle Scholar
  • 22 Wikholm G. Occlusion of cerebral arteriovenous malformations with N-butyl cyano-acrylate is permanent.  AJNR Am J Neuroradiol. 1995;  16 479-482
    PubMedGoogle Scholar
  • 23 Gruber A, Mazal P R, Bavinski G, Killer M, Budka H, Richling B. Repermeation of partially embolized cerebral arteriovenous malformations: a clinical, radiologic, and histologic study.  AJNR Am J Neuroradiol. 1996;  17 1323-1331
    PubMedGoogle Scholar
  • 24 Rao V R, Mandalam K R, Gupta A K, Kumar S, Joseph S. Dissolution of isobutyl 2-cyanoacrylate on long term follow up.  AJNR Am J Neuroradiol. 1989;  10 135-141
    PubMedGoogle Scholar
  • 25 Brown L C, Mellick P W, Smith C D et al.. Carcinogenicity bioassay of isobutyl 2-cyanoacrylate (IBC) in fischer-344 rats. NTIS/AD-A222 000/2, 1990. 
    Google Scholar
  • 26 Brown L C, Mellick P W, Smith C D et al.. Carcinogenicity bioassay of isobutyl 2-cyanoacrylate in fischer-344 rats. Report: ISS LAIR-433, Toxicology ser-187, Order No. AD-A22 2000 1990: 1161
    Google Scholar
  • 27 Brown L C, Smith C D, Lollini L O et al.. Carcinogenicity bioassay of isobutyl 2-cyanoacrylate(IBC) in fischer-344 rats-one year interim sacrifice report, Vol. 1. NTIS/AD-A195 913/9 1988
    Google Scholar
  • 28 Brown L C, Smith C D, Lollini L O et al.. Carcinogenicity bioassay of isobutyl 2-cyanoacrylate(IBC) in fischer-344 rats-one year interim sacrifice report, Vol. 2, part 1. NTIS/AD-A201 448/8 1989
    Google Scholar
  • 29 Brown L C, Smith C D, Lollini L O et al.. Carcinogenicity bioassay of isobutyl 2-cyanoacrylate(IBC) in fischer-344 rats-one year interim sacrifice report. Vol. 2, part 2. NTIS/AD-A197 679/4 1988
    Google Scholar
  • 30 Debrun G M, Aletich V, Ausman J I, Charbel F, Dujovny M. Embolization of the nidus of brain arteriovenous malformations with n-butyl cyanoacrylate.  Neurosurgery. 1997;  40 112-120
    PubMedGoogle Scholar
  • 31 Kunstlinger F, Brunelle F, Chaumont P, Doyon D. Vascular occlusive agents.  AJR Am J Roentgenol. 1981;  136 151-156
    PubMedGoogle Scholar

Robert J RosenM.D. 

Division of Interventional Radiology and Endovascular Surgery

New York University Medical Center, New York, NY

Email: Robert.rosen@med.nyu.edu