Synlett 2004(11): 2013-2015  
DOI: 10.1055/s-2004-830874
LETTER
© Georg Thieme Verlag Stuttgart · New York

Application of Hemithio Ketene Acetals to the Synthesis of Spirocyclic Orthoesters

Thomas E. La Cruz, Scott D. Rychnovsky*
Department of Chemistry, 516 Rowland Hall, University of California Irvine, Irvine, California 92697-2025, USA
Fax: +1(949)8246379; e-Mail: srychnov@uci.edu;
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Publikationsverlauf

Received 7 May 2004
Publikationsdatum:
06. August 2004 (online)

Abstract

Spirocyclic orthoesters have been synthesized by a method that employs a hemithiophenyl ketene acetal as an orthoester precursor. The orthoesters can be generated in good yields and under mild reaction conditions.

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Deactivated silica gel refers to silica gel that was first treated with Et3N, and then washed with the desired eluent.