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Synlett 2004(8): 1383-1386  
DOI: 10.1055/s-2004-829093
LETTER
© Georg Thieme Verlag Stuttgart · New York

Asymmetric Hydrogenation of 2-Arylated Cycloalkanones through Dynamic Kinetic Resolution

Takeshi Ohkuma, Jing Li, Ryoji Noyori*
Department of Chemistry and Research Center for Materials Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan
Fax: +81(52)7834177; e-Mail: noyori@chem3.chem.nagoya-u.ac.jp;
Further Information

Publication History

Received 1 March 2004
Publication Date:
22 June 2004 (online)

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Abstract

Asymmetric hydrogenation of 2-arylcycloalkanones with trans-RuCl2(binap)(1,2-diamine) and t-C4H9OK in 2-propanol selectively gives the corresponding cis-2-arylcycloalkanols in excellent enantiomeric purity and high yield. Two synthetic intermediates of biologically active compounds have been prepared by this method.

Key words

2-arylcycloalkanones - asymmetric hydrogenation - ­BINAP - dynamic kinetic resolution - ruthenium complexes

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