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DOI: 10.1055/s-2004-827240
Cytotoxic Activity of Compounds from the Lichen: Cladonia convoluta
Publication History
Received: February 25, 2004
Accepted: June 13, 2004
Publication Date:
23 September 2004 (online)
![](https://www.thieme-connect.de/media/plantamedica/200409/lookinside/thumbnails/10.1055-s-2004-827240-1.jpg)
Abstract
The depsidone 9′-(O-methyl)protocetraric acid was isolated from the lichen Cladonia convoluta (Lam.) Anders along with the known (-)-usnic acid and fumarprotocetraric acid. The complete structure of 9′-(O-methyl)protocetraric acid was elucidated using HSQC and HMBC spectral data. (-)-Usnic acid was the only compound to display a moderate cytotoxic activity on various cancer cell lines (IC50 = 6, 12.1, 15.8, 17.8, 8.2 and 6.8 μg/mL on L1210, 3LL, DU145, MCF7, K-562 and U251, respectively). This compound was also shown to induce apoptosis of murine leukaemia L1210 cells in a dose- and time-dependent manner.
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S. Tomasi
Faculté de Pharmacie
Laboratoire de Pharmacognosie et de Mycologie
2 Avenue du Professeur Léon Bernard
35043 Rennes Cedex
France
Phone: +33-223-234-817
Fax: +33-223-234-704
Email: sophie.tomasi@univ-rennes1.fr