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Planta Med 2004; 70(7): 683-685
DOI: 10.1055/s-2004-827195
Letter
© Georg Thieme Verlag KG Stuttgart · New York

New Cytotoxic Alkyl Phloroglucinols from Protorhus thouvenotii

Shugeng Cao1 , Jennifer K. Schilling1 , Armand Randrianasolo2 , Rabodo Andriantsiferana3 , Vincent E. Rasamison3 , David G. I. Kingston1
  • 1Department of Chemistry M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA
  • 2Missouri Botanical Garden, St. Louis, Missouri, USA
  • 3Centre National d'Application et Recherches Pharmaceutiques, Antananarivo, Madagascar
Biodiversity Conservation and Drug Discovery in Madagascar, Part 11. For Part 10, see ref. 1
Further Information

Publication History

Received: December 18, 2003

Accepted: April 1, 2004

Publication Date:
15 July 2004 (online)

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Abstract

Two new cytotoxic alkylene phloroglucinols and one known compound were isolated through chromatographic separation from the methanolic extract of the dried fruits of Protorhus thouvenotii (Anacardiaceae). The compounds showed marginal in vitro cytotoxicity in the A2780 ovarian cancer cell line assay with an IC50 of 11 μg/mL.

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Dr. David G. I. Kingston

Department of Chemistry

M/C 0212

Virginia Polytechnic Institute and State University

Blacksburg

Virginia 24061

USA

Phone: +1-540-231-6570

Fax: +1-540-231-3255

Email: dkingston@vt.edu