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DOI: 10.1055/s-2004-825608
Phenyl Isothiocyanate: A Very Useful Reagent in Heterocyclic Synthesis
Publication History
Publication Date:
19 May 2004 (online)
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Introduction
Naturally occurring isothiocyanates are limited in number. There is, however, a large number of synthetic isothiocyanates which constitute an important class of compounds. Thus, it is apparent that the chemistry of and from isothiocyanates has burgeoned over the years, [1] and it continues to be a blossoming field. The attraction of isothiocyanates as synthons is due to their ready availability. The most important isothiocyanate which is easily synthesized from aniline and carbon disulfide is phenyl isothiocyanate. Several heterocycles, such as thiophenes, pyrroles, pyrimidines [2] or imidazoles, [3] can be constructed from this starting material.
Figure 1
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