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Synthesis 2004(9): 1497-1503
DOI: 10.1055/s-2004-822403
DOI: 10.1055/s-2004-822403
PAPER
© Georg Thieme Verlag Stuttgart · New York
MgI2 as an Additive in Ir(I)-Catalyzed Addition of Silylacetylenes to Imines: Expeditious Synthesis of Propargylic Amines
Further Information
Publication History
Received
27 April 2004
Publication Date:
08 June 2004 (online)


Abstract
We report a dramatic improvement in the [IrCl(COD)]2-catalyzed addition reaction of silylacetylenes and imines with 2-4 mol% MgI2 as additive. The reaction is very general, with a wide range of imines providing the amine products in excellent yields under convenient reaction conditions. Importantly, the reaction can be conducted with as low as 0.5 mol% catalyst and proceeds in THF as well as in the absence of solvent.
Key words
catalysis - imines - acetylene