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Synthesis 2004(10): 1589-1594  
DOI: 10.1055/s-2004-822391
PAPER
© Georg Thieme Verlag Stuttgart · New York

‘One-Pot’ Synthesis of Chiral N-Protected α-Amino Acid-Derived 1,2,4-Oxadiazoles

Antonio L. Braga*a, Diogo S. Lüdtkea, Eduardo E. Albertoa, Luciano Dornelles*b, Wolmar A. Severo Filhob, Valeriano A. Corbellinib, Daiane M. Rosab, Ricardo S. Schwabb
a Departamento de Química, Universidade Federal de Santa Maria, 97105-900, Santa Maria, RS, Brazil
Fax: +55(55)2208031; e-Mail: albraga@quimica.ufsm.br;
b Departamento de Química e Física, Universidade de Santa Cruz do Sul, 96815-900, Santa Cruz do Sul, RS, Brazil
e-Mail: luciano@unisc.br;
Further Information

Publication History

Received 9 January 2004
Publication Date:
26 May 2004 (online)

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Abstract

A series of α-amino acid-derived 1,2,4-oxadiazoles have been synthesized via an easy, inexpensive and one-pot protocol. The heterocycles were obtained in good yields and in relatively short reaction times.

Key words

amino acids - oxadiazoles - heterocycles

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