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Synthesis 2004(6): 847-850  
DOI: 10.1055/s-2004-822315
PAPER
© Georg Thieme Verlag Stuttgart · New York

Practical Synthesis of KRN7000 from Phytosphingosine

Sanghee Kim*a,b, Soyoung Songa,b, Taeho Leea, Sungkyu Junga, Deukjoon Kimb
a Natural Products Research Institute, College of Pharmacy, Seoul National University, 28 Yungun, Jongro, Seoul 110-460, Korea
Fax: +82(2)7628322; e-Mail: pennkim@snu.ac.kr;
b College of Pharmacy, Seoul National University, San 56-1, Shilim, Kwanak, Seoul 151-742, Korea
Further Information

Publication History

Received 6 January 2004
Publication Date:
23 March 2004 (online)

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Abstract

The efficient and practical synthesis of the biologically important α-galactosylceramides, KRN7000, from phytosphingosine has been achieved in six steps in high overall yield.

Key words

sphingolipids - glycosylations - glycolipids - natural products - antitumor agents

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