Exp Clin Endocrinol Diabetes 2004; 112(9): 542-544
DOI: 10.1055/s-2004-821313
Case Report

J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Topical Application of Nerve Growth Factor in Human Diabetic Foot Ulcers. A Study of Three Cases

S. Generini1 , M. A. Tuveri2 , M. Matucci Cerinic1 , F. Mastinu2 , L. Manni3 , L. Aloe3
  • 1Department of Medicine, Section of Rheumatology, University of Florence, Italy
  • 2ASL-5 Oristano, Italy
  • 3Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy
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Publikationsverlauf

Publikationsdatum:
25. Oktober 2004 (online)

Abstract

Three diabetic patients with leg or foot ulcers unresponsive to conventional therapies were treated with topical application of Nerve Growth Factor (NGF). The results showed that NGF promotes healing after 5 - 14 weeks of treatment. This study suggests that the use of topical application of NGF may represent a new useful tool for the management of difficult diabetic ulcers.

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Dr. Luigi Aloe

Institute of Neurobiology and Molecular Medicine, CNR

Viale Marx 15

00137 Rome

Italy

Telefon: + 3968292592

Fax: + 39 6 86 09 03 70

eMail: aloe@in.rm.cnr.it